GONG Jian-ping, LIU Hui-ying, RAO Yi, et al. Optimization of Extraction Technology of Zhizhu Granules by Response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(14): 19-22.
DOI:
GONG Jian-ping, LIU Hui-ying, RAO Yi, et al. Optimization of Extraction Technology of Zhizhu Granules by Response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(14): 19-22. DOI: 10.11653/syfj2013140019.
Optimization of Extraction Technology of Zhizhu Granules by Response Surface Methodology
Objective: To optimize extraction technology of Zhizhu granules. Method: Based on single factor tests
with yield of synephrine as index
effect of water addition
extraction time and times on extraction technology of Zhizhu granules was investigated by Box-Behnken response surface methodology. Result: Optimum extraction technology was as following:took prescription amount of raw materials
reflux extracted 3 times with 490 mL water
115 min each time;Average yield of synephrine was up to 90.57%. Conclusion: Box-Behnken design was suitable for optimizing extraction technology of Zhizhu granules
the observed value approximated to the predicted value of established mathematical model.