Investigation of Immediate-Release Mechanism of -Asarone by Liquisolid Compacts

ZHAO Xu-jie; YAN Xue-sheng; XU Xin-gang; CUI Bing-bing

doi:10.11653/syfj2013140056

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Investigation of Immediate-Release Mechanism of -Asarone by Liquisolid Compacts

更新时间：2024-01-04

- Investigation of Immediate-Release Mechanism of -Asarone by Liquisolid Compacts
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 14, Pages: 56-58(2013)
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- DOI：10.11653/syfj2013140056
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- Published：2013
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ZHAO Xu-jie, YAN Xue-sheng, XU Xin-gang, et al. Investigation of Immediate-Release Mechanism of -Asarone by Liquisolid Compacts[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(14): 56-58.
DOI：

ZHAO Xu-jie, YAN Xue-sheng, XU Xin-gang, et al. Investigation of Immediate-Release Mechanism of -Asarone by Liquisolid Compacts[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(14): 56-58. DOI： 10.11653/syfj2013140056.

摘要

目的: 探讨液固压缩技术使α-细辛脑快速溶出的机制。方法: 以聚山梨酯-80为液体赋形剂

微晶纤维素PH-101为载体材料

微粉硅胶®200为涂层材料

制备药液比1:4的α-细辛脑液固压缩片

比较其与市售普通片的溶出度

通过测定X-射线衍射(XRD)和崩解时限

探讨该压缩片的速释机制。结果: 液固压缩片中α-细辛脑在5 min时

溶出度>80%。XRD表明液固压缩片中无α-细辛脑的特征峰。结论: 采用液固压缩技术可改善药物润湿性

增加药物溶出时有效表面积

使难溶性药物快速溶出。

Abstract

Objective: To investigate rapid dissolution mechanism of α-asarone by liquisolid compacts. Method: α-Asarone liquisolid tablets were prepared with solid-liquid ratio of 1:4

tween-80 as liquid excipient

microcrystalline cellulose PH-101 as carrier material

aerosil®200 as coating material.Dissolution of these liquisolid tablets and common tablets was compared

rapid release mechanism of these liquisolid tablets was investigated by measuring X-ray diffraction (XRD) and disintegration time. Result: Dissolution of α-asarone in liquisolid tablets was more than 80% in 5 min.XRD showed that there was no characteristic peaks of α-asarone in liquisolid tablets. Conclusion: Liquisolid compacts could improve drugs wetting properties and increase effective surface area of drugs dissolution

then allowing rapid dissolution of poorly soluble drugs.

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DI Jipeng

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Related Institution

Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences

School of Pharmacy，Shanxi Medical University

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Shaanxi Academy of Traditional Chinese Medicine

Shaanxi University of Chinese Medicine

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