DU Li-yue, CUI Yan-bing, GUO Liu-cheng. Optimization of Formulation Technology of Total Flavonoids from Sustained Release Tablets[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(14): 67-70.
DOI:
DU Li-yue, CUI Yan-bing, GUO Liu-cheng. Optimization of Formulation Technology of Total Flavonoids from Sustained Release Tablets[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(14): 67-70. DOI: 10.11653/syfj2013140067.
Optimization of Formulation Technology of Total Flavonoids from Sustained Release Tablets
Objective: To optimize formulation technology of total flavonoids from Bidens bipinnata sustained release tablets. Method: With hydroxypropyl methyl cellulose K4M (HPMC-K4M) as skeleton materials
starch and lactose as fillers
cumulative release of total flavonoids at three time points as comprehensive evaluation index
based on single factor tests
orthogonal test was used to investigate effect of the amount of HPMC-K4M
starch-lactose
tablets hardness and the amount of anti-adhesion on formulation technology. Result: Optimum prescription of total flavonoids from B. bipinnata was as following:the amount of HPMC-K4M 50%
starch-lactose (2:1)
tablets hardness 5 kg·mm-2
the amount of anti-adhesion(gum acacia) 2%. Conclusion: This optimized technology was stable and feasible
these prepared sustained-release tablets had good granulation