Objective: Explore the Rhizoma Musae treating Xiaoke emphasis on the fresh juicer liquid instead of dry goods decoction reasons to provide a reference for the rational utilization of Rhizoma Musae. Method: According to the clinical applications of Rhizoma Musae

petroleum ether was used to extract fresh juicer liquid and dry goods decoction

and the chemical compositions were separated

analyzed and identified by gas chromatography-mass spectrometry;peak area normalization method was applied to calculate the relative percentage of the respective components. Result: There were 54 chemical compositions identified in the petroleum ether extract of fresh juicer liquid. The relative content of palmitic acid was 3.13%. However

only 4 chemical compositions were identified in the petroleum ether extract of dry goods decoction

the palmitic acid relative content was up to 25.60%. Conclusion: The study results show that the ancient and modern literatures recorded the usage of Rhizoma Musae juicer liquid to cure ‘Xiaoke’ rather than dry goods decoction have a certain scientific reason.