Study on Pharmacokinetics of Ferulic Acid and Danshensu in GuanxinⅡ by Combination with Different Drugs

doi:10.11653/syfj2013140164

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Study on Pharmacokinetics of Ferulic Acid and Danshensu in GuanxinⅡ by Combination with Different Drugs

更新时间：2024-01-04

- Study on Pharmacokinetics of Ferulic Acid and Danshensu in GuanxinⅡ by Combination with Different Drugs
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 14, Pages: 164-168(2013)
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- DOI：10.11653/syfj2013140164
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- Published：2013
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Study on Pharmacokinetics of Ferulic Acid and Danshensu in GuanxinⅡ by Combination with Different Drugs[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(14): 164-168.
DOI：

Study on Pharmacokinetics of Ferulic Acid and Danshensu in GuanxinⅡ by Combination with Different Drugs[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(14): 164-168. DOI： 10.11653/syfj2013140164.

摘要

目的: 比较冠心Ⅱ号方不同配伍组丹参素、阿魏酸的药代动力学

揭示不同配伍对两成分体内过程的影响规律。方法: Beagle犬灌服冠心Ⅱ号各配伍方:①全方有效组分重组方;②全方中活血药有效组分重组方;③全方中理气药有效组分重组方;④全方中丹参有效组分;⑤全方中川芎有效组分。应用液-质联用(LC-MS/MS)法检测犬血浆中丹参素、阿魏酸含量

利用药代动力学软件DAS 2.0计算药代动力学参数

并比较组间差异。结果: 与含丹参的其他两组比较

全方有效组分组丹参素的峰浓度(Cmax)和药-时曲线下面积(AUC)有增高趋势;与含川芎的其他两组比较

全方有效组分重组方组阿魏酸的清除率(CL)有降低趋势

表观分布容积(V)有增高趋势

但均无统计学意义。结论: Beagle犬灌服冠心Ⅱ号有效组分不同配伍对药效成分丹参素和阿魏酸的药代动力学过程基本一致。

Abstract

Objective: To compare pharmacokinetics of danshensu(DSS) and ferulic acid(FA) in different combinations to GuanxinⅡ

and to reveal the effect of the combination to GuanxinⅡ on the process in vivo of the two main effective components. Method: Beagle dogs were administrated orally with Guanxin Ⅱin combination with different drugs:total extraction recombination

part extraction recombination propitious to blood

danshen extraction recombination

part extraction recombination propitious to breath

ligusticum wallichii extraction recombination.The plasma concentration of DSS and FA were assayed by LC-MS/MS after administration.the pharmacokinetic parameters were estimated by DAS 2.0 phamacokinetic software edited by SUN Rui-yuan

and then to compare pharmacokinetic parameters within different groups by statistic software SPSS 10.0. Result: The statistic results have showed that the pharmacokinetics of combination with different drugs to GuanxinⅡhave no significant difference

but the tendency. Conclusion: The process of danshensu and ferulic acid in vivo (Beagle dogs)are not significantly different.

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Related Author

LI Yin-chao

ZHOU Tian

SUN Man

CHEN Hui-feng

WU Cui-ping

GU Yan

PENG Juan

FAN Bin

Related Institution

School of Life Sciences，Beijing University of Chinese Medicine

School of Pharmacy，Shanghai University of Traditional Chinese Medicine

School of Graduate Studies，Tianjin University of Traditional Chinese Medicine（TCM）

The Second Affiliated Hospital of Tianjin University of TCM

First Teaching Hospital of Tianjin University of TCM

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