Effect of  Oil on Percutaneous Absorption of Salbutamol Sulfate

FU Wan-jin; WANG Dan; PANG Yu-xin; WANG Hui; HUANG Zhao; NIE Hao; YU Fu-lai; ZHANG Ying-bo

doi:10.11653/syfj2013140174

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Effect of Oil on Percutaneous Absorption of Salbutamol Sulfate

更新时间：2024-01-04

- Effect of Oil on Percutaneous Absorption of Salbutamol Sulfate
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 14, Pages: 174-177(2013)
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- DOI：10.11653/syfj2013140174
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- Published：2013
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FU Wan-jin, WANG Dan, PANG Yu-xin, et al. Effect of Oil on Percutaneous Absorption of Salbutamol Sulfate[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(14): 174-177.
DOI：

FU Wan-jin, WANG Dan, PANG Yu-xin, et al. Effect of Oil on Percutaneous Absorption of Salbutamol Sulfate[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(14): 174-177. DOI： 10.11653/syfj2013140174.

摘要

目的: 研究艾纳香油对硫酸沙丁胺醇透皮吸收的影响

为艾纳香油的应用提供理论依据。方法: 采用改良Franz扩散池装置

以豚鼠背部皮肤为体外渗透屏障

采用紫外分光光度计方法测定接收液中硫酸沙丁胺醇的含量

考察0.5%

2%艾纳香油

1%氮酮

以及1%艾纳香油与1%氮酮联合运用对硫酸沙丁胺醇透皮吸收的影响。结果: 0.5%

1.0%艾纳香油和1.0%氮酮单独应用时对硫酸沙丁胺醇透皮吸收和贮库效应均具有显著促进作用(P<0.05)。但1.0%艾纳香油与1.0%氮酮合用时其促透效果较单独使用时降低

2.0%艾纳香油对硫酸沙丁胺醇透皮吸收无显著的促进作用。结论: 低浓度的艾纳香油随着浓度升高对硫酸沙丁胺醇透皮吸收有增强作用

但高浓度艾纳香油对硫酸沙丁胺醇透皮吸收无显著促进作用。

Abstract

Objective: The effects of the Blumea balsamifera oil on percutaneous absorption of albuterol sulfate were studied. Then

a theoretical basis for the application of B. balsamifera oil was proved. Method: The effects of six different penetration enhancer programs on albuterol sulfate transdermal absorption were determined

i e

0.5%

1.0%

2.0% B. balsamifera oil

1.0% azone

1.0% B.balsamifera oil jointed with 1.0% azone and black control.Concretely

the contents of albuterol sulfate in receiving fluid were determined by UV spectrophotometer using modified Franz diffusion cell device and the excised skin from guinea pig was taken as exoteric permeability barrier. Result: 0.5%

1.0% B. balsamifera oil and 1% azone individually salbutamol sulfate transdermal absorption and storage reservoir showed a significant role in promoting (P<0.05). However

the effect of combination of 1.0% B. balsamifera oil and 1.0% azone on percutaneous penetration was lower than its using alone. Conclusion: With the increase of low concentration of B. balsamifera oil

the transdermal absorption of salbutamol sulfate enhanced. However

high concentration of B. balsamifera oil showed no significant difference.

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