Objective: To investigate the antidepressant effect and the possible mechanism of 2

3

5

4'-tetrahydroxy-stilbene-2-O-β-D-glucoside(THSG) in animal model. Method: Mail KM mice were randomly divided into 5 groups:control group (normal saline)

fluoxetine group (5 mg·kg-1)

THSG groups (200

100

50 mg·kg-1). After oral administration for 7 days

the tail-suspending test (TST)

the forced swimming test (FST) and reserpine-antagonism test were carried out to evaluate the antidepressant effects of THSG. In particular

reserpine (1 mg·kg-1)was given by intrapertioneal injection before the reserpine-antagonism test. Result: Compared with the control group

the immobility time of TST and FST was shorted in THSG high

and middle

dose group (P<0.01). Compared with the model group

THSG high

middle

dose group could significantly reverse the ptosis

and decrease body temperature induced by reserpine in mice (P<0.01

P<0.05). Conclusion: THSG has significant antidepressant effect

and its mechanism may be related to monoamine neurotransmitters.