WEI Xiu-fang, LIANG Yu-hua, LI Yuan-jin, et al. Effects of Hawthorn Leaves Flavonoids Self-emulsifying Granules on Nonalcoholic Fatty Liver in Rats[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(14): 219-221.
DOI:
WEI Xiu-fang, LIANG Yu-hua, LI Yuan-jin, et al. Effects of Hawthorn Leaves Flavonoids Self-emulsifying Granules on Nonalcoholic Fatty Liver in Rats[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(14): 219-221. DOI: 10.11653/syfj2013140219.
Effects of Hawthorn Leaves Flavonoids Self-emulsifying Granules on Nonalcoholic Fatty Liver in Rats
Objective: To investigate the effect of Hawthorn leaves flavonoids self-emulsifying granules (HLFSG) on non-alcoholic fatty liver disease. Method: Forty rats were randomized into 4 groups and fed high fat diet to induce non-alcoholic fatty liver disease model. Rosiglitazone was as the positive control group. The influence of the HLFSG(50 mg·kg-1)treatments on total cholesterol(TC)
triglyceride(TG)
low-density lipoprotein-C(LDL-C)
high-density lipoprotein-C (HDL-C)
alanine aminotransferase(ALT)
aspartate aminotransferase(AST)
free fatty acid(FFA)
superoxide dismutase (SOD)
malondialdehyde(MDA) was investigated. Result: Compared with the model group
HLFSG reduced TC
TG
LDL-C
FFA
ALT
AST
MDA significantly (P<0.05
P<0.01)
and a significant increase of HDL-C and SOD was observed. Conclusion: HLFSG is beneficial to the treatment of fatty liver through reducing blood lipid and improving the liver functions in rats.
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