Anti-fatigue Action of Different Extracts from  in Senile Mice by -Gal

PIAO Ri-long; WU Hong-mei; ZHANG Hong-ying

doi:10.11653/syfj2013140240

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Anti-fatigue Action of Different Extracts from in Senile Mice by -Gal

更新时间：2024-01-04

- Anti-fatigue Action of Different Extracts from in Senile Mice by -Gal
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 14, Pages: 240-243(2013)
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- DOI：10.11653/syfj2013140240
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- Published：2013
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PIAO Ri-long, WU Hong-mei, ZHANG Hong-ying. Anti-fatigue Action of Different Extracts from in Senile Mice by -Gal[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(14): 240-243.
DOI：

PIAO Ri-long, WU Hong-mei, ZHANG Hong-ying. Anti-fatigue Action of Different Extracts from in Senile Mice by -Gal[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(14): 240-243. DOI： 10.11653/syfj2013140240.

摘要

目的: 研究马齿苋不同提取物对D-半乳糖致衰老小鼠抗疲劳能力的影响

并探讨其机制。方法: 取小鼠随机分为正常组、模型组、马齿苋正丁醇提取物(0.5

0.25 g·kg-1)组、马齿苋乙醇提取物(1

0.5 g·kg-1)组。除正常组sc生理盐水外

其他各组均sc D-半乳糖(1 g·kg-1)42 d制备衰老小鼠模型。用疲劳仪测定小鼠的抗疲劳能力

并测定脑组织丙二醛(MDA)含量和超氧化物歧化酶(SOD)活性。结果: 马齿苋正丁醇提取物(0.5 g·kg-1)和乙醇提取物(1 g·kg-1)组均可提高衰老小鼠的抗疲劳能力

马齿苋正丁醇提取物(0.5

0.25 g·kg-1)可降低脑组织MDA含量和提高SOD活性

马齿苋乙醇提取物(1 g·kg-1)可降低脑组织MDA含量。结论: 马齿苋正丁醇提取物和乙醇提取物可提高衰老小鼠的抗疲劳能力

其机制可能与提高SOD活性降低MDA含量有关。马齿苋正丁醇提取物作用好于乙醇提取物。

Abstract

Objective: To study the anti-fatigue action of different extracts from Portulaca oleracea in senile mice by D-gal

and its mechanisms. Method: The mice were randomly divided into 4 groups:control group

model group

the n-butanol extracts from P. oleracea(0.5

0.25 g·kg-1) groups and the ethanol extracts from P. oleracea(1

0.5 g·kg-1) groups. The control group is given hypodermic injection of isotonic NaCl in the transverse part while the other groups successively administered by hypodermic injection of D-gal(1 g·kg-1). It is made a model of senile mice after 42 d continuation. To measure anti-fatigue performances with the Fatigue Instrument. To measure malondialdehyde(MDA) contents and superoxide dismutase(SOD) activity in brain tissue of senile mice. Result: The n-butanol extract from P. oleracea (0.5 g·kg-1) and the ethanol extract from P. oleracea(1 g·kg-1) could improve anti-fatigue performances.The n-butanol extracts from P. oleracea(0.5

0.25 g·kg-1) could decrease MDA contents and SOD activity in brain tissue. The ethanol extract from P. oleracea (1 g·kg-1) could decrease MDA contents n brain tissue. Conclusion: The n-butanol extract from P. oleracea and the ethanol extract from P. oleracea can improve anti-fatigue performances. Its mechanism maybe related by improve SOD activity and decrease MDA contents. The n-butanol extract from P. oleracea is better than the ethanol extract from P. oleracea.

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