GONG Jian-wei, YE Lei, ZHANG Xiu-li, et al. Effects of Dihuang Yinzi on the SOD, CAT, GSH-Px Activities and MDA Contents in the Serum and Brain of Cerebral Ischemia-reperfusion Model Rats[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(14): 247-250.
DOI:
GONG Jian-wei, YE Lei, ZHANG Xiu-li, et al. Effects of Dihuang Yinzi on the SOD, CAT, GSH-Px Activities and MDA Contents in the Serum and Brain of Cerebral Ischemia-reperfusion Model Rats[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(14): 247-250. DOI: 10.11653/syfj2013140247.
Effects of Dihuang Yinzi on the SOD, CAT, GSH-Px Activities and MDA Contents in the Serum and Brain of Cerebral Ischemia-reperfusion Model Rats
Objective: To explore the mechanism of Dihuang Yinzi in ameliorating the damage induced by cerebral ischemia-reperfusion. Method: Sixty SD rats were selected and randomly divided into six groups:sham group
model group
Dihuang Yinzi high
medium
low dose group(32
16
8 g·kg-1) and nimodipine positive drug group(1 mg·kg-1)
each group include 10 rats. The cerebral ischemia-reperfusion model was established after 7 days drug administration. The activities of superoxide dismutase(SOD)
catalase (CAT)
glutathione peroxidase (GSH-Px) and the content of malonaldehyde(MDA) in the serum and brain of rats were observed at 120 min after the cerebral ischemia-reperfusion. Result: The activitis of SOD
CAT and GSH-Px were lower and the contents of MDA were higher in serum and brain of mode1 rats than normal rats.Dihuang Yinzi could increase the activitis of SOD
CAT and GSH-Px and decrease the content of MDA. Conclusion: Dihuang Yinzi can ameliorate the oxidative damage induced by cerebral ischemia-reperfusion.