Effect of Zhishi Xiebai Guizhi Decoction on MMP-9, TIMP-1 Levels and Gene Expression in Patients with Unstable Angina

DAI Fei; LU Shu; SU Wei; GONG Shao-nan

doi:10.11653/syfj2013140307

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Effect of Zhishi Xiebai Guizhi Decoction on MMP-9, TIMP-1 Levels and Gene Expression in Patients with Unstable Angina

更新时间：2024-01-04

- Effect of Zhishi Xiebai Guizhi Decoction on MMP-9, TIMP-1 Levels and Gene Expression in Patients with Unstable Angina
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 14, Pages: 307-310(2013)
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- DOI：10.11653/syfj2013140307
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- Published：2013
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DAI Fei, LU Shu, SU Wei, et al. Effect of Zhishi Xiebai Guizhi Decoction on MMP-9, TIMP-1 Levels and Gene Expression in Patients with Unstable Angina[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(14): 307-310.
DOI：

DAI Fei, LU Shu, SU Wei, et al. Effect of Zhishi Xiebai Guizhi Decoction on MMP-9, TIMP-1 Levels and Gene Expression in Patients with Unstable Angina[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(14): 307-310. DOI： 10.11653/syfj2013140307.

摘要

目的: 探讨枳实薤白桂枝汤对血瘀、痰浊、气滞、寒凝为主的不稳定型心绞痛(UA)患者基质金属蛋白酶9(MMP-9)、基质金属蛋白酶抑制剂1(TIMP-1)水平及其基因表达的影响及其作用机制。方法: UA患者60例

按随机原则

将患者划分为对照组和治疗组

每组各30例。酶联免疫标记(ELISA)测定血清MMP-9

TIMP-1水平

实时荧光定量PCR技术进行相对定量检测MMP-9

TIMP-1基因表达

比较两组MMP-9

TIMP-1水平及其基因表达的变化。结果: 两组患者症候积分较治疗前均有改善(P<0.05)

且治疗组优于对照组(P<0.05)。两组患者MMP-9

TIMP-1水平较治疗前均有改善(P<0.05)

且治疗组优于对照组(P<0.05)。两组患者MMP-9

TIMP-1 mRAN较治疗前均有改善(P<0.05)

MMP-9/TIMP-1 mRAN比较

治疗组优于对照组(P<0.05)。结论: 在规范化治疗的基础上加用枳实薤白桂枝汤可进一步改善UA患者MMP-9

TIMP-1水平及其基因表达

促进粥样斑块的稳定性。

Abstract

Objective: To explore the effect and mechanism of Zhishi Xiebai Guizhi decoction on matris metalloproteinases-9(MMP-9)

tissue inhibitor of metalloproteinase(TIMP-1) levels and gene expression in patients with blood stasis

sputum

qi stagnation

cold obstruction unstable angina (UA). Method: Sixty UA patients were divided into control group(30)and treatment group(30) randomly. ELISA was used to determine the serum MMP-9

TIMP-1 levels. Real time fluorescent quantitative PCR was used to determine MMP-9

TIMP-1 gene expression. Compared the serum MMP-9

TIMP-1 levels and gene expression from the two group. Result: The two groups had significant improvements in Symptom integra after treatment(P<0.05)

and the treatment group were superior to the control group(P<0.05).The two groups had significant improvements in Serum levels of MMP-9

TIMP-1 after treatment(P<0.05).and the treatment group were superior to the control group(P<0.05). The two groups had significant improvements in MMP-9

TIMP-1 mRAN after treatment(P<0.05). The treatment group were superior to the control group in MMP-9/TIMP-1mRAN(P<0.05). Conclusion: Based on the standardization of treatment

Zhishi Xiebai Guizhi decoction can improve the serum MMP-9

TIMP-1 levels and gene expression in patients with blood stasis

sputum

qi stagnation

cold obstruction UA

and advance the stability of atherosclerosis plaque.

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