Objective: To explore the effect of Yiqi Huayu Lishui decoction (YQHYLSD) on vascular endothelial growth factor (VEGF) and urinary albumin excretion rate (UAER) in patents of early diabetic nephropathy combined with HIV/AIDS. Method: Fifty six cases of early diabetic nephropathy combined with HIV/AIDS were randomly divided into two groups. Two groups were received routine western medicine treatment and antivirus. The treatment group was treated with YQHYLSD one dose daily for 3 months. The levels of plasma VEGF in the two groups were measured by immunohistochemisty and enzyme linked immunosorbent assay. The urinary albumin excretion was measured to calculate UAER. Result: The plasma levels of VEGF and UAER in treatment group were significantly lower then those of control group

and the outcome in treatment group was more effective then that in the control group(P<0.05). Conclusion: VECG and UAER play an important role in the pathogenesis of early diabetic nephropathy patients combined with HIV/AIDS. YQHYLSD can degrade VEGF and UAER levels of early diabetic nephropathy patients

which is one of possible mechanism of YQHYLSD protecting the renal function.