YIN Li, ZHENG Wen-ling, SUN Qi-zhe, et al. Meta-analysis of Efficiency in Treatment of Gastric Cancer by Compound Kushen Injection Combined with Chemotherapy[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(14): 325-330.
DOI:
YIN Li, ZHENG Wen-ling, SUN Qi-zhe, et al. Meta-analysis of Efficiency in Treatment of Gastric Cancer by Compound Kushen Injection Combined with Chemotherapy[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(14): 325-330. DOI: 10.11653/syfj2013140325.
Meta-analysis of Efficiency in Treatment of Gastric Cancer by Compound Kushen Injection Combined with Chemotherapy
Objective: To evaluate the safety and efficacy of compound Kushen injection (CKI) as adjunctive treatment of patients with advanced gastric cancer (AGC). Method: A computer-based online search of literatures prior to March 2012 was performed in Medline
the Cochrane Library
EMBASE
CENTRAL
PubMed
Google Scholar
CNKI
CBM
VIP and Wanfang by using a combination of synonyms for compound kushen injection
gastric cancer and chemotherapy. Randomized controlled trials(RCT)of CKI as adjunctive treatment for AGC were included. Bias risks of included RCT studies were evaluated and homogeneity studies were Meta-analyzed by Revman 5.1 software. Result: Twelve RCT studies including 1 004 patients were involved in this research. Pooling data of the Meta-analysis indicated that compared with chemotherapy alone
the combination had a statistically significant benefit in total effect rate [OR=1.51
95%CI (1.18
1.94)
P=0.001]
quality of life improvement rate [OR=1.95
95%CI (1.49
2.55)
P<0.000 01] and improved the incidence of Leukopenia [OR=0.36
95%CI (0.26
0.50)
P<0.000 01]. Conclusion: The results of this Meta-analysis confirmed that CKI plus chemotherapy shows a good efficacy and an acceptable safety profile in AGC patients
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Related Author
HUANG Yi-xue
GUO Yu-ming
SANG Xiu-xiu
SHEN Hong-hui
MA Xiao
LIU Shi-jing
XIAO Xiao-he
CHEN Jiaping
Related Institution
Beijing Hospital of Traditional Chinese Medicine, Capital Medical University
Beijing Key Laboratory for Quality Evaluation of Chinese Materia Medical/Traditional Chinese Medicine(TCM) Processing Technology Inheritance Base of National Administration of TCM, School of Chinese Materia Medica, Beijing University of Chinese Medicine
The First Clinical Medical School of Henan University of Chinese Medicine
The First Affiliated Hospital of Henan University of Chinese Medicine
Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases Co-constructed by Henan Province and Education Ministry of P.R. China/Henan Key Laboratory of Chinese Medicine for Respiratory Disease,Henan University of Chinese Medicine