Research on Disposition of Osthol and Compatibility of its Components and Pharmaceutical Methods Application

YUN Fei; DI Liu-qing; CHEN Le-tian; CAI Bao-chang; SHAN Jin-jun; ZHAO Xiao-li; KANG An

doi:10.11653/syfj2013140347

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Research on Disposition of Osthol and Compatibility of its Components and Pharmaceutical Methods Application

更新时间：2024-01-04

- Research on Disposition of Osthol and Compatibility of its Components and Pharmaceutical Methods Application
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 14, Pages: 347-350(2013)
- 作者机构：
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- DOI：10.11653/syfj2013140347
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- Published：2013
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YUN Fei, DI Liu-qing, CHEN Le-tian, et al. Research on Disposition of Osthol and Compatibility of its Components and Pharmaceutical Methods Application[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(14): 347-350.
DOI：

YUN Fei, DI Liu-qing, CHEN Le-tian, et al. Research on Disposition of Osthol and Compatibility of its Components and Pharmaceutical Methods Application[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(14): 347-350. DOI： 10.11653/syfj2013140347.

摘要

以中药蛇床子亲脂性活性成分蛇床子素为对象

分析了蛇床子素的吸收、分布、代谢、排泄制征等体过程

静脉注射、腹腔注射、口服蛇床子的药物动力学特征及组分配伍及药剂学技术应用对蛇床子素体内过程的影响。结果显示难溶性中药活性成分蛇床子素膜渗透性好

但是生物利用度较低

组分配伍可影响其体内过程

改善其生物利用度。改善和提高中药活性成分生物利用度不仅可以应用药剂学技术

也可体现在中药组分合理配伍之中

对进一步开展剂型设计和生物有效性评价具有极其重要的意义。

Abstract

To analyze effective methods for improving and enhancing the bioavailability of the active ingredients in the traditional Chinese medicine (TCM). On the basis of summarizing and analyzing the biopharmaceutical and pharmacokinetic characteristics of osthol

the main active ingredient of fructus cnidii

pharmaceutical methods and components compatibility are proposed to have influence on the bioavailability and disposition of osthol. Osthol

as a poorly water soluble drug

had a good permeability

but bioavailability was poor. Pharmaceutical methods and components compatibility are helpful to improve the poor bioavailability of osthol. To improve and enhance the bioavailability of the active ingredients in the TCM

we can not only resort to pharmaceutical methods

but also the reasonable application of components compatibility between the TCM.

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Related Author

GAO Jie

LI Shiyang

GUO Jing

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JIAN Fengjiao

HUANG Kexin

Related Institution

Wuya College of Innovation，Shenyang Pharmaceutical University

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School of Pharmacy，Soochow University

School of Chinese Materia Medica，Shanghai University of Traditional Chinese Medicine

School of Pharmacy，Fujian University of Traditional Chinese Medicine

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