Screening of  Transdermal Enhancer of Odynolysis Cataplasms

ZHOU Fu-jun; SHAN Qi; HOU Wen-bin; HUA Jie; GUO Yuan-qiang

doi:10.11653/syfj2013150020

您当前的位置：

首页 >

文章列表页 >

Screening of Transdermal Enhancer of Odynolysis Cataplasms

更新时间：2024-01-04

- Screening of Transdermal Enhancer of Odynolysis Cataplasms
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 15, Pages: 20-23(2013)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.11653/syfj2013150020
  CLC：
- Published：2013
- 稿件说明：
移动端阅览
ZHOU Fu-jun, SHAN Qi, HOU Wen-bin, et al. Screening of Transdermal Enhancer of Odynolysis Cataplasms[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(15): 20-23.
DOI：

ZHOU Fu-jun, SHAN Qi, HOU Wen-bin, et al. Screening of Transdermal Enhancer of Odynolysis Cataplasms[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(15): 20-23. DOI： 10.11653/syfj2013150020.

摘要

目的: 优选止痛巴布剂的体外透皮促进剂。方法: 采用Franz扩散池

以磷酸缓冲液pH 7.4为接收介质

经白兔腹部离体皮肤渗透

HPLC测定阿魏酸含量

计算药物累积透皮量和累积渗透率

考察透皮吸收促进剂氮酮、N-甲基-2-吡咯烷酮、丙二醇单独使用或混合使用对阿魏酸体外经皮渗透效果的影响。结果: 最佳透皮促进剂为3%氮酮+3%丙二醇。N-甲基-2-吡咯烷酮几乎不能增加阿魏酸的透过量

单独加入2%氮酮使阿魏酸透过率增加1.7倍

单独加入3%丙二醇使阿魏酸得透过率增加1.4倍

3%氮酮与3%丙二醇联合使用使阿魏酸的透过率约增加2.2倍。结论: 3%氮酮+3%丙二醇作为止痛巴布剂的透皮促进剂效果最好。

Abstract

Objective: To optimize in vitro transdermal enhancer of odynolysis cataplasms. Method: Franz diffusion cell was adopted with pH 7.4 phosphate buffer as receiving medium

in vitro skin permeation studies of ferulic acid were conducted across excised rabbit abdominal skin.The content of ferulic acid was determined by HPLC to calculate cumulative doses of skin permeation and cumulative penetration rate.Effect of used alone or mixed use of azone

N-methyl-2-pyrrolidone and propylene glycol on in vitro transdermal of ferulic acid was investigated. Result: Optimum transdermal enhancer was 3% azone+3% propylene glycol

it could increase about 2.2 times of transdermal amount of ferulic acid.N-methyl-2-pyrrolidone could hardly increase transdrmal amount of ferulic acid

alone adding 2% azone could increase 1.7 times and 3% propylene glycol increased 1.4 times. Conclusion: 3% Azone+3% propylene glycol could be as transdermal enhancer for odynolysis cataplasms with optimum effect.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Percutaneous Penetration of Main Active Ingredient from Fufang Kali Ziran Gel

Effects of Different Permeation Enhancer on Percutaneous Absorption of Naringin in Sanwei Dieda Rheumatism Gel Paste

Combination of Components from Tripterygii Radix et Rhizoma-Chuanxiong Rhizoma Affects RA-FLSs by Regulating NF-κB， Nrf2/HO-1 Signaling Pathways and Bcl-2/Caspase-3 Expression

Cloning and Expression Patterns of Coumarate-3-hydroxylase Gene from Angelica sinensis and Its Correlation with Content of Ferulic Acid

Chronic Toxicity of Triptolide and Ferulic Acid Ethosomes Gel for Percutaneous Administration

Related Author

XING Jian-guo

WANG Xin-chun

ZHAO Yuan

MA Jian-hong

XUE Gui-peng

LIU Gui-hua

YIN Shan-shan

WANG Yan-qiu

Related Institution

Laboratory Animal Science and Technology Center，Jiangxi University of Chinese Medicine

National Key Laboratory of Modern Chinese Medicine Creation of Classic Prescriptions

Jiangxi University of Chinese Medicine，Key Laboratory of Modern Preparation of Traditional Chinese Medicine，Ministry of Education

School of Life Science And Technology， Wuhan Polytechnic University

Puren Hospital Affiliated to Wuhan Science & Technology University

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰