OU Wei-ye, HUANG Juan-ping, CAI Yan-qu, et al. Comparative Analysis of Pharmacokinetic Parameters of Chuanping Compound in Rats and Human[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(15): 162-166.
DOI:
OU Wei-ye, HUANG Juan-ping, CAI Yan-qu, et al. Comparative Analysis of Pharmacokinetic Parameters of Chuanping Compound in Rats and Human[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(15): 162-166. DOI: 10.11653/syfj2013150162.
Comparative Analysis of Pharmacokinetic Parameters of Chuanping Compound in Rats and Human
Objective: To compare in vivo pharmacokinetic parameters of Chuanping compound in rats and human. Method: HPLC was adopted for determining the concentration of ephedrin and pseudoephedrine in SD rats blood and human urine
pharmacokinetic parameters in rats blood and human urine were calculated by 3P87 software and urine drug deficiency
respectively. Result: Pharmacokinetic parameters of chuanping compound in rats and human were not the same
interaction of Ephedra sinica and Datura metel had no significant effect on metabolism of ephedrin and pseudoephedrine in rats
but it had influence in human. Conclusion: Metabolic process was different between drugs with high dosage in animals and drugs with normal dose in human.In vivo metabolic process of animals with high dosage could not accurately reflect drugs in human.
Excretion of Ephedrines in Human Urine after Oral Administration of Mahuang Tang Decoction
Effect of Chuanping Compound on IgE,Transforming Growth Factor-beta 1 and Tumor Necrosis Factor-alpha in BALF of Guinea Pig with Asthma
Optimization of Extraction Technology for Effective Ingredients from Majie Pingchuan Cataplasma by Orthogonal Test and Transdermal Characteristic Investigation
Transdermal Test of Ephedrine and Pseudoephedrine from Tianxing Kechuan Patches in Rats
Analysis of Material Basis and Mechanism of Ephedrae Herba-Armeniacae Semen Amarum Medicine Pair Based on Intestinal Absorption Fluid Containing Drug
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