Effect of Kuijieling Decoction Contained Serum on Cell Proliferation in Caco-2 Cell Injury Model

ZHANG Han; WANG Wei-ming; LI Yan-wu; WU Yan-li; WANG Ru-jun

doi:10.11653/syfj2013150167

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Effect of Kuijieling Decoction Contained Serum on Cell Proliferation in Caco-2 Cell Injury Model

更新时间：2024-01-04

- Effect of Kuijieling Decoction Contained Serum on Cell Proliferation in Caco-2 Cell Injury Model
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 15, Pages: 167-170(2013)
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- DOI：10.11653/syfj2013150167
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- Published：2013
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ZHANG Han, WANG Wei-ming, LI Yan-wu, et al. Effect of Kuijieling Decoction Contained Serum on Cell Proliferation in Caco-2 Cell Injury Model[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(15): 167-170.
DOI：

ZHANG Han, WANG Wei-ming, LI Yan-wu, et al. Effect of Kuijieling Decoction Contained Serum on Cell Proliferation in Caco-2 Cell Injury Model[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(15): 167-170. DOI： 10.11653/syfj2013150167.

摘要

目的: 观察溃结灵含药血清对Caco-2细胞损伤模型细胞增殖的影响。方法: 应用三硝基苯磺酸灌肠法复制溃疡性结肠炎大鼠模型

3 d后采集血液

分离血清

作为损伤剂作用于Caco-2细胞一段时间

模拟细胞炎性损伤模型

MTT法观察不同浓度溃结灵含药血清对Caco-2细胞损伤模型细胞增殖的影响。结果: 与模型血清组比较

10%

2.5%

1.25%

0.625%溃结灵含药血清作用Caco-2细胞损伤模型24 h后

有促进其增殖的作用

尤以10%溃结灵含药血清效果最佳(P<0.05)。结论: 溃结灵含药血清可促进Caco-2细胞炎性损伤后细胞增殖。

Abstract

Objective: To investigate the effect of Kuijieling decoction contained serum on cell proliferation in Caco-2 cell injury model. Method: Rectal instillation of trinitrobenzenesulfonic acid (TNBS) was used to establish the rats model of ulcerative colitis

3 days later blood simples were collected and serum was separated

which was used to intervene Caco-2 cells for a period of time to simulate cell inflammatory injury model

the effect of different concentrations of Kuijieling decoction contained serum oncell proliferation was observed by the method of MTT. Result: Compared with the model serum group

10%

2.5%

1.25%

0.625% of Kuijieling decoction contained serum promoted proliferation

especially 10% of Kuijieling decoction contained serum was best(P<0.05). Conclusion: Kuijieling decoction contained serum could promote the proliferation of Caco-2 cells after injury.

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