Objective: The skin protection of scallop shells extract in vitro was studied. Method: There were some bioactive components in scallop shells. The extract of Patinopecten yessoensis scallop shell was used to evaluate the skin protection by observation of skin fibroblast cells TIG-101(MTT assay) and collagen synthesis(direct red 80%). Result: The result indicated that the bioactive components of scallop shells could enhance the bioactivity of chymotrypsin

but had a strong inhibitory effect on the bioactivity of elastase and trypsin;enhance cell proliferation of the skin fibroblast(P<0.05) and collagen synthesis(P<0.05). Conclusion: These results indicate that the components of the scallop shell contain the biological active substances that protect the skin tissue.