Influence of Yiqi Huatan Decocotion and its Component on the Level of Plasm Copper,Zinc in Rat Depression Model

BAI Lin; HAN Yong-zhu; ZHOU Hai-hong; ZHOU Zhi-hua; WANG Xun

doi:10.11653/syfj2013150198

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Influence of Yiqi Huatan Decocotion and its Component on the Level of Plasm Copper,Zinc in Rat Depression Model

更新时间：2024-01-04

- Influence of Yiqi Huatan Decocotion and its Component on the Level of Plasm Copper,Zinc in Rat Depression Model
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 15, Pages: 198-201(2013)
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- DOI：10.11653/syfj2013150198
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- Published：2013
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BAI Lin, HAN Yong-zhu, ZHOU Hai-hong, et al. Influence of Yiqi Huatan Decocotion and its Component on the Level of Plasm Copper,Zinc in Rat Depression Model[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(15): 198-201.
DOI：

BAI Lin, HAN Yong-zhu, ZHOU Hai-hong, et al. Influence of Yiqi Huatan Decocotion and its Component on the Level of Plasm Copper,Zinc in Rat Depression Model[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(15): 198-201. DOI： 10.11653/syfj2013150198.

摘要

目的: 探讨益气化痰方(人参、清半夏、陈皮、茯苓)及其拆方对慢性轻度不可预知应激(CUMS)模型大鼠血清锌、铜含量的影响。方法: 健康雄性SD大鼠60只

随机分为5组。采用Katz刺激方法制备CUMS抑郁模型。在应激的第2天开始

按前期工作中得出了相应的效应中药及其各拆方最佳药物配比熬制中药浓缩剂

调节锌、铜方(3.25 g·kg-1组)和益气化痰方(7.0 g·kg-1)组按提取液10 mL·kg-1灌胃

阳性药物组按10 mg·kg-1ig马普替林混悬液给药

模型组和正常对照组按10 mL·kg-1给予等量的生理盐水

持续给药至第23天。实验过程中

定期测定水平得分、竖直得分、修饰次数、大便颗粒数及糖水消耗量。于第23天处死大鼠

采集血样。采用原子吸收法测定各组大鼠血清锌、铜水平的含量。结果: 采用孤养和CUMS刺激方法成功制备动物抑郁模型。模型组血清铜含量较正常组明显升高、血清锌含量较正常组明显降低;而益气化痰方组与模型组比较均能够逆转上述改变;其中调节锌铜方组可以显著提高血清锌的水平及降低血清铜水平。结论: 益气化痰方具有良好的抗抑郁作用

同时能逆转大鼠行为学、体内微量元素锌和铜的改变;其中起主要作用的可能为调节锌铜方药。

Abstract

Objective: To explore the effects of Yiqi Huatan Fang(YQHTF) and its component on the serum copper

zinc in chronic unpredictable mild stress(CUMS) model in rats. Method: Sixty male rats were divided into five groups randomly.The depression model was established by chronic unpredictable mild stress (CUMS) and living individually. On the second day

the adjusting zinc and copper group (3.25 g·kg-1) and the YQHTF group 7.0 g·kg-1 were administrated the diluent by intragastric injection with 10 mL·kg-1. The positive drug group was administrated the maprotiline by intragastric injection with 10 mg·kg-1.The model group and the control group were administrated the saline by intragastric injection with 10 mL·kg-1.During the experiment

the data of open-field test and the percentage of sucrose preference were detected.On day 23

all the rats were decapitated after the last treatment

then blood was immediately isolated for detecting the concentration of the level of serum copper and zinc by atomic absorption method. Result: The depression model was successfully established. Compared with control group

the serum copper level in the model rats was increased significantly and the serum zinc level was decreased significantly. YQHTF could reverse all these changes.The adjusting zinc and copper group could significantly increase the level of serum zinc and decrease the level of serum copper. Conclusion: YQHTF and its component have a good effect of anti-depression. It can improve the behavior of the depressed rats

increase serum copper level and decrease serum zinc level significantly in depressed rats. The adjusting zinc and copper group is likely the major components of YQHTF.

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