Effects of Glucosidorum Tripterygll Totorum Tablet on Serum HMGB1 and IL-17 in Rats with Collagen-induced Arthritis

ZHENG Hong-mei; JIN Song

doi:10.11653/syfj2013150247

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Effects of Glucosidorum Tripterygll Totorum Tablet on Serum HMGB1 and IL-17 in Rats with Collagen-induced Arthritis

更新时间：2024-01-04

- Effects of Glucosidorum Tripterygll Totorum Tablet on Serum HMGB1 and IL-17 in Rats with Collagen-induced Arthritis
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 15, Pages: 247-250(2013)
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- DOI：10.11653/syfj2013150247
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- Published：2013
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ZHENG Hong-mei, JIN Song. Effects of Glucosidorum Tripterygll Totorum Tablet on Serum HMGB1 and IL-17 in Rats with Collagen-induced Arthritis[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(15): 247-250.
DOI：

ZHENG Hong-mei, JIN Song. Effects of Glucosidorum Tripterygll Totorum Tablet on Serum HMGB1 and IL-17 in Rats with Collagen-induced Arthritis[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(15): 247-250. DOI： 10.11653/syfj2013150247.

摘要

目的: 观察雷公藤多苷片对胶原诱导性关节炎(collagen induced arthritis

CIA)大鼠血清中高迁移率族蛋白B1(high mobility group box chromosomal protein 1

HMGB1)及白介素17(interleukin 17

IL-17)含量的影响。方法: 40只SD大鼠被随机分为正常对照组、模型对照组、甲氨喋呤对照组(3 mg·kg-1)、雷公藤多苷片低、高剂量组(5

10 mg·kg-1)。用牛Ⅱ型胶原蛋白加不完全氟氏佐剂诱导大鼠关节炎模型

于免疫12 d开始灌胃给药

连续4周。CIA大鼠模型建立后

观察各组大鼠关节指数变化

并采用ELISA法检测各组大鼠血清中HMGB1和IL-17的含量。结果: 与正常组比较

模型组大鼠关节肿胀明显

血清中HMGB1和IL-17含量明显升高 (P<0.01或P<0.05);与模型组比较

各治疗组大鼠关节肿胀程度均有一定程度缓解

甲氨喋呤组和雷公藤多苷片高剂量组大鼠血清中HMGB1和IL-17的含量显著低于模型组(P<0.01或P<0.05)。结论: 雷公藤多苷片治疗CIA大鼠关节肿胀可能与降低血清中HMGB1

IL-17的含量相关。

Abstract

Objective: To study the effects of glucosidorum tripterygll totorum (GTT) tablet on serum high mobility group box chromosomal protein 1(HMGB1) and interleukin 17 (IL-17)in rats with collagen-induced arthritis. Method: Forty SD male rats were randomly divided into normal group

model group

methotrexate group(3 mg·kg-1)

GTT tablet low dose group(5 mg·kg-1)

and GTT tablet high dose(10 mg·kg-1)group.Collagen induced arthritis model was made by bovine type II collagen. The medicines were given to relevant groups 12 hours after the establishment of the model once a day for 4 weeks

then the changes of arthritis index(AI) were estimated

and the contents of HMGB1 and IL-17 were analyzed by ELISA. Result: The results showed that the AI of treated groups were significant different from CIA group. Compared with the normal control group rats

the contents of HMGB1 and IL-17 were increased significantly in CIA group rats (P<0.01 or P<0.05). Compared with the CIA group rats

the contents of HMGB1 and IL-17 were decreased significantly both in GTT tablet high dose group rats and methotrexate group rats (P<0.01 or P<0.05). Conclusion: GTT tablet can improve the joint swell in CIA rats

it may be associated with lower HMGB1

IL-17 expression correlated.

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