Objective: To compare the effect of engineering Niuhuang Jiangya capsule (ENJC) and artificial Niuhuang Jiangya capsule (ANJC) on blood pressure in spontaneously hypertension rats (SHR). Method: SHR were randomly divided into 7 groups in accordance with the systolic blood pressure:model control group

ANJC group and enalapril control group

and ENJC groups (80%

60%

30%

10% alternated respectively). SHR were given oral drug for 14 d accordingly. ALC-NIBP blood pressure monitoring system was employed to determine blood pressure before drug given and at 5 h

6

10

14 d after drug administration

the blood pressure of 3

7 d after drug application was also monitored. Result: After administration of 5 h

the rats of 80% ENJC showed significantly(P<0.05)reduced blood pressure

compared with the control group. On the 6 d of administration 80% and 60% ENJC showed significant antihypertensive effect

and the reduced DBP tended to be stable. After taking drug for 14 days

the hypotensive effect of 80% ENJC was most obvious. ENJC of 80% and 60% had significant effect of reducing heart rate. The function is proportional to the dose of ENJC. ANJC did not show the similar effect. Conclusion: Antihypertensive effect of ENJC is better than the original ANJC

with less dose

rapid onset and stonger and lasting effect.