Efficacy of Combined Therapy of Jiawei Zuojin Pill and Triple Therapy for Gastric Ulcer and the Influence on Trefoil Factor and Epidermal Growth Factor

HOU Feng-xia; LI Kun; ZHANG Xiao-li

doi:10.11653/syfj2013150298

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Efficacy of Combined Therapy of Jiawei Zuojin Pill and Triple Therapy for Gastric Ulcer and the Influence on Trefoil Factor and Epidermal Growth Factor

更新时间：2024-01-04

- Efficacy of Combined Therapy of Jiawei Zuojin Pill and Triple Therapy for Gastric Ulcer and the Influence on Trefoil Factor and Epidermal Growth Factor
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 15, Pages: 298-301(2013)
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- DOI：10.11653/syfj2013150298
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- Published：2013
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HOU Feng-xia, LI Kun, ZHANG Xiao-li. Efficacy of Combined Therapy of Jiawei Zuojin Pill and Triple Therapy for Gastric Ulcer and the Influence on Trefoil Factor and Epidermal Growth Factor[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(15): 298-301.
DOI：

HOU Feng-xia, LI Kun, ZHANG Xiao-li. Efficacy of Combined Therapy of Jiawei Zuojin Pill and Triple Therapy for Gastric Ulcer and the Influence on Trefoil Factor and Epidermal Growth Factor[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(15): 298-301. DOI： 10.11653/syfj2013150298.

摘要

目的: 探讨加味左金丸联合三联疗法对胃溃疡(GU)的疗效及对血清三叶因子(TFF2)及表皮生长因子(EGF)的影响。方法: 将80例活动期GU(肝胃郁热证)患者随机分为治疗组和对照组各40例。对照组口服奥美拉唑肠溶胶囊(20 mg/次

2次/d)

克拉霉素胶囊(0.25 g/次

2次/d)

阿莫西林胶囊(0.5 g/次

2次/d)。治疗组在对照组基础上加用加味左金丸

6 g/次

2次/d。两组疗程均为4周。观察肝胃郁热证积分、胃镜疗效及幽门螺旋杆菌(HP)清除率

并检测血清TFF2及EGF水平。结果: 治疗组肝胃郁热证总积分及各症状评分均明显低于对照组(P<0.01);治疗组溃疡面积(0.17±0.21)cm2

低于对照组的(0.28±0.24)cm2(P<0.05);治疗组胃镜疗效总有效率97.5%

对照组为92.5%

无统计学差异;治疗组HP清除率为84.8%

对照组清除率为67.6%

治疗组优于对照组(P<0.01);两组治疗后TFF2、EGF均较治疗前上升

治疗组TFF2、EGF水平均明显高于对照组(P<0.01)。结论: 加味左金丸提高血清中金丸可以显著提高三联疗法对胃溃疡的疗效

其作用机制可能与提高TFF2及EGF有关。

Abstract

Objective: To observe the efficacy of combined therapy of Jiawei Zuojin pill and triple therapy for gastric ulcer (GU) and the influence on trefoil factor (TFF2) and epidermal growth factor (EGF). Method: 80 patients with GU (the stagnated heat syndrome in the liver and stomach) were randomly divided into treated group (n=40) and control group (n=40). Patients in the control group received triple therapy

that is Omeprazole Enteric-coated capsules Azithromycin (20 mg

two times per day)

Clarithromycin Capsules (0.5 g

two times per day) and Amoxicillin capsules (0.5 g

two times per day

oral). Jiawei Zuojin pill (6 g

two times per day) combined with triple therapy was administrated to patients in the treated group. The course is last for 4 weeks. The score of stagnated heat syndrome in the liver and stomach

eradication rate of Helicobacter pylori (HP)

efficacy of endoscopy and TFF2 and EGF levels in Serum were observed. Result: The score of stagnated heat syndrome in the liver and stomach in the treated group was significantly lower than that of control group(P<0.01). Ulcer area of treatment group (0.17±0.21)cm2 was significantly lower than that of control group(P<0.05).There was no significant difference in total efficiency between treated group (97.5%) and control groups (92.5%).Curative effect of TCM syndromes in the treated group were significantly better than the control group(P<0.01). Eradication rate of HP of the treated group(84.8%) was better than that of the control group (67.6%)(P<0.01). After treatment

TFF2 and EGF levels in treatment group were significantly higher than that of the control group

though levels of the two cytokines in both group increased. Conclusion: Jiawei Zuojin pill can significantly improve the curative effect of triple therapy for gastric ulcer

the mechanism may be related to the increasing of TFF2 and EGF.

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