Efficacy of Compound Matrine Injections Intrapleural Perfusion Combined with Fuzhenxiaoshui-prescrip Oral in Treatment of Malignant Pleural Effusion Clinical Observation of 44 Cases

QIN Qing-yin; LU Fang-yang; HUANG Gui-jia; ZHANG Li; KANG Zhi-min; HE Yong-mei

doi:10.11653/syfj2013150306

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Efficacy of Compound Matrine Injections Intrapleural Perfusion Combined with Fuzhenxiaoshui-prescrip Oral in Treatment of Malignant Pleural Effusion Clinical Observation of 44 Cases

更新时间：2024-01-04

- Efficacy of Compound Matrine Injections Intrapleural Perfusion Combined with Fuzhenxiaoshui-prescrip Oral in Treatment of Malignant Pleural Effusion Clinical Observation of 44 Cases
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 15, Pages: 306-309(2013)
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- DOI：10.11653/syfj2013150306
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- Published：2013
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QIN Qing-yin, LU Fang-yang, HUANG Gui-jia, et al. Efficacy of Compound Matrine Injections Intrapleural Perfusion Combined with Fuzhenxiaoshui-prescrip Oral in Treatment of Malignant Pleural Effusion Clinical Observation of 44 Cases[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(15): 306-309.
DOI：

QIN Qing-yin, LU Fang-yang, HUANG Gui-jia, et al. Efficacy of Compound Matrine Injections Intrapleural Perfusion Combined with Fuzhenxiaoshui-prescrip Oral in Treatment of Malignant Pleural Effusion Clinical Observation of 44 Cases[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(15): 306-309. DOI： 10.11653/syfj2013150306.

摘要

目的: 探讨复方苦参注射液胸腔灌注配合扶正消水方内服治疗恶性胸腔积液的临床疗效。方法: 将87例恶性胸腔积液患者随机按数字法分为对照组43例和观察组44例。两组均以中心静脉导管胸腔内置管闭式引流胸腔积液

对照组采用顺铂进行胸腔内注射

观察组用复方苦参注射液配合顺铂行胸腔内注射

并采用扶正消水方内服。疗程均为3周。监测胸腔积液量

评价患者生存质量

记录临床症状、体征的改善情况及不良反应。结果: 观察组缓解率(CR+PR)为84.1%优于对照组的58.13%(P<0.01);观察组生存质量改善情况优于对照组(P<0.05);观察组呼吸困难

咳嗽

胸痛的改善均明显优于对照组(P<0.05);观察组出现胸痛、胃肠道反应的患者明显少于对照组(P<0.05)。结论: 在西医常规治疗的基础上

采用复方苦参注射液胸腔灌注加扶正消水方内服治疗恶性胸腔积液

能减轻临床症状

提高患者的生存质量

减轻化疗的毒副作用

值得临床推广使用。

Abstract

Objective: To investigate the clinical efficacy of compound matrine injections intrapleural perfusion combined with Fuzhenxiaoshui-prescrip oral in the treatment of malignant pleural effusion. Method: Eighty-seven patients with malignant pleural effusion were divided into the control group of 43 cases and the observation group 44 cases according to random number. Central venous drainage placed in pleural was used in the two groups. Cisplatin was intrapleurally injected in the control group. The observation group was treated with the compound matrine injection and Fuzhenxiaoshui-prescrip oral besides cisplatin intrapleural injection. Course of treatment was three weeks. The amount of pleural effusion was monitored. Quality of life in patients was evaluated. Clinical symptoms and signs and adverse reactions were recorded. Result: Remission rate (CR+PR) of the observation group was 84.1%

which was higher than 58.13% of the control group (P<0.01). The quality of life of the observation group was improved compared with the control group (P<0.05). Clinical symptoms and signs

such as dyspnea

cough and chest pain of the observation group was significantly improved compared with the control group (P<0.05). The number of cases of chest pain and gastrointestinal reactions of the observation group was significantly less than the control group (P<0.05). Conclusion: On the basis of conventional Western medicine treatment

compound matrine injections intrapleural perfusion combined with "Fuzhenxiaoshui-prescrip" oral

can increase the clinical efficacy of malignant pleural effusion

improve the patient's quality of life

and reduce the side effects of chemotherapy. Therefore

it is worth to be widely used clinically.

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