Objective: To observe influence of Guizhi Fuling pill combined with berberine on polycystic ovary syndrome (PCOS) with insulin resistance patients. Method: One hundred and twelve cases with PCOS were randomly divided into observation group (Guizhi Fuling pill combined with berberine) and control group (diane-35 combined with metformin)

glucose metabolism

lipid levels

sex hormone levels

clinical manifestations and ovulation and pregnancy were observed before and after treatment. Result: After the treatment

the level of fasting insulin(FINS)

homeostasis model assessment of insulin resistance(HOMA-IR) was decreased significantly (P<0.05). Fasting plasma glucose (FPG)

FINS

HOMA-IR between two groups had no difference (P>0.05). The level of total cholesterol (TC)

triglycerides cholesterol (TG) in observe group were significantly decreased (P>0.05). High-density lipoprotein cholesterol(HDL-C) in two groups increased significantly

especially degree of HDL-C in observation group was better than that in control grousignificantly (P<0.05). Luteinizing hormone(LH)

LH/FSH

estriol(E2)in two groups decreased significantly and follicle-stimulating hormone (FSH)

E2 increased significantly (P<0.05 or 0.01). especially The improvement degree of LH

LH/FSH

E2

oligomenorrhea

acne

ovarian volume in observation group was better than those in control group (P<0.05). Ovulation was significantly higher than that in control group (P<0.05). Conclusion: Guizhi Fuling pill combined with berberine can decrease insulin resistance

changing the fasting insulin and androgen levels in different ways

improving insulin sensitivity

restoring menstrual cycle

improving the pregnancy rate.