Optimization of Preparation Technology of Total Glucosides of Buyang Huangwu Decoction Capsules

ZOU Long; LI Huan-huan; LIU Hui; DENG Chang-qing

doi:10.11653/syfj2013160008

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Optimization of Preparation Technology of Total Glucosides of Buyang Huangwu Decoction Capsules

更新时间：2024-01-04

- Optimization of Preparation Technology of Total Glucosides of Buyang Huangwu Decoction Capsules
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 16, Pages: 8-11(2013)
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- DOI：10.11653/syfj2013160008
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- Published：2013
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ZOU Long, LI Huan-huan, LIU Hui, et al. Optimization of Preparation Technology of Total Glucosides of Buyang Huangwu Decoction Capsules[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(16): 8-11.
DOI：

ZOU Long, LI Huan-huan, LIU Hui, et al. Optimization of Preparation Technology of Total Glucosides of Buyang Huangwu Decoction Capsules[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(16): 8-11. DOI： 10.11653/syfj2013160008.

摘要

目的: 优选补阳还五汤总苷胶囊的制备工艺。方法: 以出膏率和黄芪甲苷含量为指标

采用正交试验优选补阳还五汤总苷胶囊的水提取工艺。采用732型阳离子交换树脂、三氯甲烷萃取和DA-201型大孔树脂对补阳还五汤中总苷类物质进行分离、纯化

通过单因素试验考察优选该制剂的成型工艺。结果: 最佳水提取工艺为加10

8倍量水提取2次

每次1 h。选择乳糖为吸湿剂

80%乙醇为润湿剂

生产环境相对湿度应<60%

1.02 g颗粒应分装入6粒2号胶囊中。结论: 优选的提取、成型工艺条件合理可行

为补阳还五汤总苷胶囊的工业化生产提供参考。

Abstract

Objective: To optimize preparation process of total glucosides of Buyang Huanwu decoction(BYHWT) capsules. Method: With the content of astragaloside Ⅳ and extract yield as indexes

water extraction process of this capsules was optimized by orthogonal design.Isolation and purification of total glucosides from BYHWT was achieved by using 732 cation exchange resin firstly

then extracting with chloroform

and finally using DA-201 macroporous resin.Molding technology of this capsules was investigated by single factor tests. Result: Optimum water extraction technology was:extracted 2 times with 10

8 times the volume of water

1 h per time.Lactose as hygroscopic agent

80% ethanol as wetting agent

relative humidity should be less than 50% for production environment

1.02 g particles should be dispensed into 6 No. 2 capsules. Conclusion: Optimized extraction and molding technology was reasonable and feasible

which provided a reference for industrial production of total glucosides of BYHWT capsules.

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