Preparation and Characterization of Gentiopicroside Nano-lipid Carriers

ZHANG Kun-chi; LV Shao-wa; LIU Lu; LI Xin; LI Yong-ji

doi:10.11653/syfj2013160015

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Preparation and Characterization of Gentiopicroside Nano-lipid Carriers

更新时间：2024-01-04

- Preparation and Characterization of Gentiopicroside Nano-lipid Carriers
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 16, Pages: 15-18(2013)
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- DOI：10.11653/syfj2013160015
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- Published：2013
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ZHANG Kun-chi, LV Shao-wa, LIU Lu, et al. Preparation and Characterization of Gentiopicroside Nano-lipid Carriers[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(16): 15-18.
DOI：

ZHANG Kun-chi, LV Shao-wa, LIU Lu, et al. Preparation and Characterization of Gentiopicroside Nano-lipid Carriers[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(16): 15-18. DOI： 10.11653/syfj2013160015.

摘要

目的: 制备龙胆苦苷纳米脂质载体(GEN-NLC)

进行性质表征及稳定性、体外释放情况考察。方法: 采用溶剂分散法制备GEN-NLC

以粒径、Zeta电位及包封率为指标

考察固/液脂质的比例、药脂比、表面活性剂种类及浓度等对GEN-NLC制备工艺的影响

通过透射电镜观察其形态

并进行稳定性、体外释药考察。结果: 最佳处方为选用0.1%泊洛沙姆188为表面活性剂

药脂比1:10

液态脂质的比例10%。制备的GEN-NLC包封率(38.19±1.61)%

载药量(3.47±0.08)%

粒径(129.9±3.07)nm

PDI (0.264±0.01)

Zeta电位(-22.5±0.42) mV。GEN-NLC为球形粒子且呈单分散分布

外观圆整

大小均一

于4℃下放置30 d

包封率、粒径和Zeta电位均无明显变化

在4 h时仅释放39.65%

36 h时累积释放量达79.86%。结论: 溶剂分散法制备的GEN-NLC具有较好的理化性质和稳定性

且具备一定的缓释长效作用。

Abstract

Objective: To prepare gentiopicroside nano-lipid carriers(GEN-NLC) and investigate its stability

in vitro release and properties. Method: Solvent dispersion method was used to prepare GEN-NLC.With particle size

Zeta potential and encapsulation efficiency as indexes

effects of proportion of solid-liquid lipid

drug-lipid ratio and the type and concentration of surfactant on preparation technology were investigated

morphology of prepared GEN-NLC was observed by transmission electron microscopy

its characteristics and stability was investigated. Result: Optimal prescription was as following:0.1% poloxamer 188 as surfactant

drug-lipid ratio 1: 10

liquid lipid ratio 10%.Encapsulation efficiency of prepared GEN-NLC was (38.19±1.61)%

drug loading was(3.47±0.08)%

particle size was(129.9±3.07) nm

PDI was (0.264±0.01)

Zeta potential was (-22.5±0.42) mV. GEN-NLC was spherical particles and showed monodisperse distribution

rounded appearance and uniform size.After stored at 4℃ for 30 d

indicators were not changed significantly

release of gentiopicroside 39.65% in 4 h

cumulative release amounted to 79.86% at 36 h. Conclusion: It showed that there were good physicochemical properties and stability of GEN-NLC prepared by solvent dispersion method

and had a certain degree of sustained-release long-lasting effect.

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