SUN Xiao-ping, LV Xin-yong, LIU Li-na, et al. Effect of Tianshu Capsule on Migarine Model Induced by Reserpine[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(16): 210-212.
DOI:
SUN Xiao-ping, LV Xin-yong, LIU Li-na, et al. Effect of Tianshu Capsule on Migarine Model Induced by Reserpine[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(16): 210-212. DOI: 10.11653/syfj2013160210.
Effect of Tianshu Capsule on Migarine Model Induced by Reserpine
Objective: To study the effect and mechanism of Tianshu capsule on the migraine's mice
which was composed of Gastrodiae Rhizoma and Ligustici Chuanxiong Rhizoma. Method: Model was building on ICR mice after subcutaneous injection of reserpine 0.1 mg·kg-1·d-1×12 d
control group mice were injected 0.9% sodium chloride injection
treatment were started on the seventh day of modeling for 6 consecutive days
dose were 1.55
4.65 g·kg-1. The pain threshold was tested on the twelve day
the clotting time was tested next day and concentration of serotonin (5-HT)
noradrenaline(NA) in the brain.was detected. Zolmitriptan tablets were used as a positive durg. Result: Compared with model group
the tianshu capsule could increase the pain threshold(P<0.01)
prolong the clotting time(P<0.01)
increase the concentration of 5-HT and NA in brain(P<0.05
P<0.01). Compared with positive drug
the capsule could increase the concentration of 5-HT(P<0.05). Conclusion: The capsule can treat the migraine's mice by balancing release of 5-HT
inhibiting vascular dilatation of migraine attacks.
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XIAO Wei
LIU Fu-you
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FANG Zheng-long
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ZHAO Xiaoxiao
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Related Institution
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Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences
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Henan Provincial Hospital of Traditional Chinese Medicine/The Second Affiliated Hospital of Henan University of Chinese Medicine
Graduate School of Anhui University of Chinese Medicine