FAN Wen-tao, WANG Qian, LIU Bai-yan. Influence of Dihuang Yinzi on the Content of Serotonin Receptors in Hippocampal of Rat with Poststroke Depression[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(16): 224-228.
DOI:
FAN Wen-tao, WANG Qian, LIU Bai-yan. Influence of Dihuang Yinzi on the Content of Serotonin Receptors in Hippocampal of Rat with Poststroke Depression[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(16): 224-228. DOI: 10.11653/syfj2013160224.
Influence of Dihuang Yinzi on the Content of Serotonin Receptors in Hippocampal of Rat with Poststroke Depression
Objective: To observe influence of of Dihuang Yizi (DHYZ) on serotonin 1 A receptor (5-HT1AR) and serotonin 2 A receptor (5-HT2AR) mRNA express in poststroke depression rats
and further discuss mechanism. Method: The sixty healthy adult SD rats were randomly divided into 6 groups including blank control group
model group
the optimal solutions group
DHYZ high dose group
medium group
low group. Afterpoststroke depression model was established the corresponding drugs were given (hydrochloric acid prozac
DHYZ 450
150
75 mg·kg-1. The real-time fluorescent quantitative RT-PCR method was used to assay 5-HT1AR and 5-HT2AR mRNA expression. Result: Compared with model group; DHYZ medium (0.76± 0.13)
(1.21±0.21) and high dose groups (0.75±0.1)
(11.25±0.26) increased the 5-HT1AR mRNA expression
and decreased the 5-HT2AR mRNA expression (P<0.05). Conclusion: DHYZ may raise 5-HT1AR mRNA
and decrease 5-HT2AR mRNA
which can explain mechanism of DHYZ in treatment of poststroke depression.
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