Protection Effect and Antioxidation of  Polysaccharide on Liver Function in Cisplatin-induced Hepatotoxicity Rats

LI Chao-yan; ZHOU Yuan-yuan; WANG Fu-qing; GUO Fu-lian

doi:10.11653/syfj2013160229

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Protection Effect and Antioxidation of Polysaccharide on Liver Function in Cisplatin-induced Hepatotoxicity Rats

更新时间：2024-01-04

- Protection Effect and Antioxidation of Polysaccharide on Liver Function in Cisplatin-induced Hepatotoxicity Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 16, Pages: 229-231(2013)
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- 作者简介：
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- DOI：10.11653/syfj2013160229
  CLC：
- Published：2013
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LI Chao-yan, ZHOU Yuan-yuan, WANG Fu-qing, et al. Protection Effect and Antioxidation of Polysaccharide on Liver Function in Cisplatin-induced Hepatotoxicity Rats[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(16): 229-231.
DOI：

LI Chao-yan, ZHOU Yuan-yuan, WANG Fu-qing, et al. Protection Effect and Antioxidation of Polysaccharide on Liver Function in Cisplatin-induced Hepatotoxicity Rats[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(16): 229-231. DOI： 10.11653/syfj2013160229.

摘要

目的: 观察黄精多糖(Polygonatum sibiricum polysaccharide

PSP)对顺铂(cisplatin

CP)致大鼠肝损害的保护作用及抗氧化指标的影响。方法: 采用ip顺铂5 mg·kg-1的方法制备肝损害模型

将40只大鼠随机分为5组:空白组、模型组、PSP低、中、高剂量组(10

40 g·kg-1);分别ig处理10 d

采血检测血清丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)水平;处死后剪取肝测定肝脏系数

肝组织匀浆后检测超氧化物歧化酶(SOD)、丙二醛(MDA)及谷胱甘肽过氧化物酶(GSH-Px)含量;同时观察肝脏组织学结构变化。结果: 与空白组比较

模型组大鼠血清ALT

AST含量均显著升高(P<0.01)

肝组织匀浆中SOD

GSH-Px均下降(P<0.01)

而MDA含量升高(P<0.01)。与模型组比较

PSP作用后大鼠血清ALT

AST含量均明显降低(P<0.05或P<0.01)

肝组织匀浆中SOD

GSH-Px均明显升高(P<0.05或P<0.01)

MDA含量明显下降(P<0.05或P<0.01)。结论: 黄精多糖可明显降低顺铂致大鼠肝功能损伤

其机制可能与其抗氧化作用有关。

Abstract

Objective: To study the protection effect of Polygonatium sibiricum polysaccharide(PSP) on cisplatin-induced hepatotoxicity. Method: Forty Sprague-Dawley rats were randomly divided into normal control group

model group

the low dosage group

the middle dosage group and the high dosage group of PSP

with eight rats in each group. The model rats with hepatotoxicity were duplicated with injection of cisplatin(5 mg·kg-1). The rats were injected with cisplatin(5 mg·kg-1) after fifth days rats in the low

middle and high dosage group of PSP were treated by PSP 10

40 g·kg-1 once a day. After 10 days of administration with PSP

the changes of liver coefficient were examined and the blood alanine aminotrans ferase(ALT)

aspartate amino transferasen(AST)

the activity of superoxide dismutase(SOD)

glutathione peroxidase(GSH-Px) and the content of malondialdehyde(MDA) was measured. Result: Compared with the normal control group

contents of ALT

AST in serum were significantly increased in each treatment group(P<0.01)

the content of MDA was significantly increased(P<0.01) and the activity of SOD and GSH-Px was significantly decreased(P<0.01). Compared with the model group

contents of ALT

AST in serum were significantly decreased in each treatment group(P<0.05 or P<0.01)

the content of MDA was significantly decreased(P<0.05 or P<0.01) and the activity of SOD and GSH-Px was significantly increased(P<0.05 or P<0.01). Conclusion: PSP may improve the function in liver injury rats induced by cisplatin and inhibite the oxidative damage of liver.

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