Effect of Interval Time and Different Dosages on Induced Labor Outcome on Mid Pregnancy by Misoprostol in Vaginal

CHEN Hui-juan

doi:10.11653/syfj2013160315

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Effect of Interval Time and Different Dosages on Induced Labor Outcome on Mid Pregnancy by Misoprostol in Vaginal

更新时间：2024-01-04

- Effect of Interval Time and Different Dosages on Induced Labor Outcome on Mid Pregnancy by Misoprostol in Vaginal
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 16, Pages: 315-317(2013)
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- DOI：10.11653/syfj2013160315
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- Published：2013
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CHEN Hui-juan. Effect of Interval Time and Different Dosages on Induced Labor Outcome on Mid Pregnancy by Misoprostol in Vaginal[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(16): 315-317.
DOI：

CHEN Hui-juan. Effect of Interval Time and Different Dosages on Induced Labor Outcome on Mid Pregnancy by Misoprostol in Vaginal[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(16): 315-317. DOI： 10.11653/syfj2013160315.

摘要

目的: 研究米索前列醇内置阴道后穹窿不同剂量及不同间隔时间对中期妊娠的引产结局。方法: 将150例拟行药物引产的中期妊娠孕妇随机分为观察组及对照组

每组75例

两组均采取米索前列醇内置阴道后穹窿引产

观察组每次用药间隔4 h

每次200 μg

24 h最大剂量800 μg;对照组每次用药间隔时间6 h

每次400

24 h最大剂量1 200 μg;观察并对比两组孕妇引产结局。结果: 两组孕妇引产成功率、阴道出血量比较均无统计学意义;观察组宫缩发动时间、总产程明显、用药剂量明显低于对照组(P<0.05)

药物不良反应发生率比对照组显著降低(P<0.01)。结论: 采取米索前列醇内置阴道后穹窿行中期妊娠引产时

每次200 μg

间隔4 h给药

引产安全有效

适合临床推广。

Abstract

Objective: To study the effect of different doses and intervals time on induction outcome on the middle pregnancy by misoprostol in vagina. Method: One hundred and fifty pregnant women who were to be executed misoprostol induction were divided into observation group and control group

two group were given misoprostol induction

in observation group the interval time was 4 h

at the doae of 200 μg

during 24 hour the maximum dose reaching 800 μg. In the control group the interval time was 6 h

at the dose of 400 μg and 1 200 μg;the pregnant women labor outcome was observed and compared. Result: The success rate

amount of vaginal bleeding in two groups were not statistically significant; in the observation group the time of uterine contraction

the total production process and the dosage were lower than that in the control group (P<0.05)

the incidence of adverse drug reactions was significantly lowe than that in the control group(P<0.01). Conclusion: Misoprostol at dose of 200 μg and 4 h of interval time is safe effective and suitable for clinical application.

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