Effects of Different Compatibility on Contents of Monoester-Alkaloids from Aconiti Radix Cocta in Aconitum Decoction

ZHANG Yan; GUI Shu-hua; XIE You-liang; TAN Qing-long; LU Rui-qi; LI Guo-wei; QIU Ji-yuan

doi:10.11653/syfj2013170011

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Effects of Different Compatibility on Contents of Monoester-Alkaloids from Aconiti Radix Cocta in Aconitum Decoction

更新时间：2024-01-04

- Effects of Different Compatibility on Contents of Monoester-Alkaloids from Aconiti Radix Cocta in Aconitum Decoction
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 17, Pages: 11-14(2013)
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- DOI：10.11653/syfj2013170011
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- Published：2013
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ZHANG Yan, GUI Shu-hua, XIE You-liang, et al. Effects of Different Compatibility on Contents of Monoester-Alkaloids from Aconiti Radix Cocta in Aconitum Decoction[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(17): 11-14.
DOI：

ZHANG Yan, GUI Shu-hua, XIE You-liang, et al. Effects of Different Compatibility on Contents of Monoester-Alkaloids from Aconiti Radix Cocta in Aconitum Decoction[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(17): 11-14. DOI： 10.11653/syfj2013170011.

摘要

目的: 考察乌头汤不同配伍对制川乌中3种单酯型乌头生物碱(苯甲酰乌头原碱、苯甲酰新乌头原碱、苯甲酰次乌头原碱)含量的影响。方法: 采用HPLC考察乌头汤不同配伍中3种单酯型乌头生物碱含量的变化。结果: 与制川乌单煎相比

配伍黑豆、防风的乌头汤与原乌头汤中单酯型乌头生物碱含量由1 338.86 μg分别降至349.26

402.18 μg

制川乌配伍防风则降低至680.01 μg

制川乌配伍黑豆则降至667.59 μg。结论: 乌头汤配伍防风、黑豆能很大程度地降低制川乌中3种单酯型乌头碱含量

为揭示制川乌减毒配伍机制提供指导。

Abstract

Objective: To investigate influence of different compatibility to the contents of three kinds of monoester-alkaloids (benzoylmesaconine

benzoylaconine

benzoylhypaconine) from Aconiti Radix Cocta in aconitum decoction. Method: HPLC was applied to determine the contents of three kinds of monoester-alkaloids from Aconiti Radix Cocta in aconitum decoction with different compatibility. Result: Compared with single fried of Aconiti Radix Cocta

the contents of monoester-alkaloids in aconitum decoction felt from 1 338.86 μg to 349.26

402.18 μg by compatibility with black beans and Saposhnikoviae Radix

compatibility of Aconiti Radix Cocta and Saposhnikoviae Radix reduced to 680.01 μg

and felt to 667.59 μg in compatible decoction of Aconiti Radix Cocta and black beans. Conclusion: Compatibility of Saposhnikoviae Raidix and black beans could reduce to a large extent contents of three kinds of monoester-alkaloids from Aconiti Radix Cocta

it provided guidance for revealing attenuated compatibility mechanism of Aconiti Radix Cocta.

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Related Author

CHEN Jian-zhen

LV Gui-yuan

LUO Xiao-min

YE Lei

XU Qun1

OUYANG Zhen2

CHANG Yu2

FU Dong-sheng3

Related Institution

Department of Pharmacy,Hebei North University

Shandong University of Traditional Chinese Medicine

Affiliated Hospital of Shandong University of Traditional Chinese Medicine

Pharmaceutical Department of North China Coal Medical University

Henan Provincial Engineering Technology Research Center for Quality Control and Evaluation of Traditional Chinese Medicine， Henan University of Chinese Medicine

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