Objective: To optimize formulation of seabuckthorn flavonoids extract dispersible tablets by central composite design-response surface methodology. Method: With disintegration time

suspension coefficient and tensile strength as dependent variables

the amounts of PVPP

HPC and PVP-K30 as independent variables

formulation was optimized by central composite design

data was fitted by multiple linear and binomial nonlinear equations

response surface methodology was adopted to determine optimum formulation. Result: Optimal formulation was proposed to contain PVPP 50.0 mg/table

HPC 9.2 mg/table and PVP-K30 7.0 mg/table.Dissolution test of optimal formulation indicated that there was low deviation (0.32%) between the predicted value and the measured value. Conclusion: Central composite design-response surface methodology was convenient to optimize molding technology of seabuckthorn flavonoids extract dispersible tablets

optimized molding technology was stable and feasible.