Content and Release Degree Determination of Sinomenine Transdermal Patch

WANG Ying; WANG Yan

doi:10.11653/syfj2013170146

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Content and Release Degree Determination of Sinomenine Transdermal Patch

更新时间：2024-01-04

- Content and Release Degree Determination of Sinomenine Transdermal Patch
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 17, Pages: 146-148(2013)
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- DOI：10.11653/syfj2013170146
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- Published：2013
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WANG Ying, WANG Yan. Content and Release Degree Determination of Sinomenine Transdermal Patch[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(17): 146-148.
DOI：

WANG Ying, WANG Yan. Content and Release Degree Determination of Sinomenine Transdermal Patch[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(17): 146-148. DOI： 10.11653/syfj2013170146.

摘要

目的: 测定青藤碱透皮贴剂的含量及体外释放度。方法: 采用HPLC

Hypersil C18色谱柱(4.6 mm×250 mm

5 μm)

流动相为甲醇-水-乙二胺(50:50:0.25)

流速1.0 mL·min-1

柱温室温

检测波长265 nm。结果: 青藤碱透皮贴剂的平均回收率为98.97%

RSD 1.90%(n=6);暂定6

72 h的累积释放率分别为9.6%~14.4%

30.4%~45.6%

45.2%~67.8%。结论: 建立的含量及释放度的测定方法简便、重复性好

可用于该产品的质量控制。

Abstract

Objective: To determine the content and release degree of sinomenine transdermal patch. Method: HPLC analysis was adopted in the determination

and the chromatographic conditions were as follows:the column was Hypersil C18 (4.6 mm×250 mm

5 μm). The mobile phase was methanol-water-ethylenediamine (50:50:0.25). The elution rate was 1.0 mL·min-1. The column was kept at room temperature. The detection wavelength was set at 265 nm. Result: The average recovery and RSD were 98.97% and 1.90% (n=6) respectively. The cumulative release ratio at 6

24 and 72 hours was confirmed temporarily as 9.6%-14.4%

30.4%-45.6% and 45.2%-67.8%. Conclusion: The methods for content and release degree determination are simple and repeatable

which could be used for the quality control of the preparation.

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Related Institution

Scientific Research Center， Gannan Medical University

Beijing Key Laboratory of Traditional Chinese Medicine Basic Research on Prevention and Treatment of Major Diseases，Experimental Research Center， China Academy of Chinese Medical Sciences

Institute of Innovation and Applied Research in Chinese Medicine， Hunan University of Chinese Medicine

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Hunan Zhengqing Pharmaceutical Group Co. Ltd.

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