Effects of Different Compatibility Proportions of Lonicerae Japonicae Flos and Forsythiae Fructus on Dissolution of Active Ingredients and  Pharmacokinetics in Rats

LIN Yi-ning; GAO Ru; ZHANG Meng; GAO Yuan

doi:10.11653/syfj2013170180

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Effects of Different Compatibility Proportions of Lonicerae Japonicae Flos and Forsythiae Fructus on Dissolution of Active Ingredients and Pharmacokinetics in Rats

更新时间：2024-01-04

- Effects of Different Compatibility Proportions of Lonicerae Japonicae Flos and Forsythiae Fructus on Dissolution of Active Ingredients and Pharmacokinetics in Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 17, Pages: 180-183(2013)
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- DOI：10.11653/syfj2013170180
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- Published：2013
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LIN Yi-ning, GAO Ru, ZHANG Meng, et al. Effects of Different Compatibility Proportions of Lonicerae Japonicae Flos and Forsythiae Fructus on Dissolution of Active Ingredients and Pharmacokinetics in Rats[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(17): 180-183.
DOI：

LIN Yi-ning, GAO Ru, ZHANG Meng, et al. Effects of Different Compatibility Proportions of Lonicerae Japonicae Flos and Forsythiae Fructus on Dissolution of Active Ingredients and Pharmacokinetics in Rats[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(17): 180-183. DOI： 10.11653/syfj2013170180.

摘要

目的: 比较金银花-连翘药对配伍前后及不同配伍比例煎出液中绿原酸、连翘苷、连翘酯苷A的溶出量

考察配伍比例对绿原酸在大鼠体内药动学行为的影响。方法: 采用HPLC测定金银花-连翘单煎、共煎提取物中绿原酸、连翘苷、连翘酯苷A的含量;分别给予大鼠灌胃金银花-连翘1:1

1:2共煎提取物(剂量为绿原酸60 mg·kg-1)

测定血浆中绿原酸浓度

用 DAS软件根据非房室模型法计算药动学参数。结果: 绿原酸和连翘苷在共煎提取物中含量高于单煎提取物

而连翘酯苷A在药对中煎出量低于连翘单煎液。金银花-连翘(1:1

1:2)共煎提取物的药时曲线下面积(AUC0-t) 分别为0.95

1.19 mg·h·L-1

Cmax分别为0.18

0.26 mg·L-1

药动学行为无显著差异。结论: 金银花-连翘配伍有助于绿原酸和连翘苷的溶出

但连翘酯苷A的溶出量减少。不同配伍比例的金银花-连翘提取物按相同绿原酸剂量给药

绿原酸在大鼠体内的药动学参数无明显差异。

Abstract

Objective: To compare dissolution of chlorogenic acid

phillyrin and forsythoside A in decoction of different compatibility proportions of Lonicerae Japonicae Flos and Forsythiae Fructus

and investigate effects of different compatibility proportions on in vivo pharmacokinetics of chlorogenic acid in rats. Method: HPLC was adopted to determine the contents of chlorogenic acid

phillyrin and forsythoside A in single decoction and co-decoction of Lonicerae Japonicae Flos and Forsythiae Fructus;Rats were intragastric adiministrated co-decoction of Lonicerae Japonicae Flos and Forsythiae Fructus with ratio of 1: 1 and 1: 2 (dosage of chlorogenic acid was 60 mg·kg-1)

then the concentration of chlorogenic acid was determined

pharmacokinetic parameters were calculated with DAS software by non-compartment model. Result: The contents of chlorogenic acid and phillyrin in co-decoctions were higher than that in single decoctions

but the content of forsythoside A was decreased when Lonicerae Japonicae Flos and Forsythiae Fructus decocted together.After intragastric adiministrated co-decoction of Lonicerae Japonicae Flos and Forsythiae Fructus with ratio of 1: 1 and 1: 2

AUC0-t were 0.95

1.19 μg·h·mL-1

and Cmax were 0.18

0.26 mg·L-1

respectively;Pharmacokinetics had no significant difference. Conclusion: Dissolution of chlorogenic acid and phillyrin were increased with compatibility of Lonicerae Japonicae Flos and Forsythiae Fructus

while forsythoside A was decreased in co-decoctions.Pharmacokinetic parameters of chlorogenic acid showed no significant differences between 1: 1 and 1: 2 decoctions at the same dosage of chlorogenic acid.

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