Absorption Characteristics Investigation of Extract from Toosendan Fructus in Rat Everted Gut Test

WANG Lan; Wang Wei; YANG Wei-peng; LIANG Ri-xin; LI Peng-yue; WANG Yan-li; HU Nan; CHENG Long; HOU Rui; WANG Yi-wei; YIN Xiao-jie

doi:10.11653/syfj2013170184

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Absorption Characteristics Investigation of Extract from Toosendan Fructus in Rat Everted Gut Test

更新时间：2024-01-04

- Absorption Characteristics Investigation of Extract from Toosendan Fructus in Rat Everted Gut Test
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 17, Pages: 184-187(2013)
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- DOI：10.11653/syfj2013170184
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- Published：2013
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WANG Lan, Wang Wei, YANG Wei-peng, et al. Absorption Characteristics Investigation of Extract from Toosendan Fructus in Rat Everted Gut Test[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(17): 184-187.
DOI：

WANG Lan, Wang Wei, YANG Wei-peng, et al. Absorption Characteristics Investigation of Extract from Toosendan Fructus in Rat Everted Gut Test[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(17): 184-187. DOI： 10.11653/syfj2013170184.

摘要

目的: 采用肠外翻模型观察川楝子提取物在大鼠十二指肠、空肠、回肠及结肠段的吸收特征。方法: 采用大鼠肠外翻模型

通过HPLC检测肠吸收液中川楝素(TSN)含量

计算吸收速率参数

以分析川楝素在肠道不同部位的吸收特征。结果: 不同质量浓度的TSN在各肠段均为线性吸收

R2均>0.95

符合零级吸收;TSN的吸收速率常数均随川楝子提取物质量浓度的增加而显著增加

表现为被动吸收。川楝素在十二指肠、空肠、回肠吸收较好

且无显著性差异

但在结肠处吸收较差。结论: TSN在肠道不同部位吸收均符合零级吸收速率

吸收形式可能为被动吸收。

Abstract

Objective: To observe absorption characteristics of extract from Toosendan Fructus in duodenum

jejunum

ileum and colon segment by rat everted gut model. Method: Toosendanin(TSN) which was representative compositions of extract from Toosendan Fructus in rat everted gut test was detected by HPLC

and absorption rate parameter to describe absorption characteristics of TSN in different parts of intestine was calculated. Result: Absorption of TSN with different concentration was linearity in different intestines

square of coefficient correlation all exceed 0.95

which consistent with zero order absorption.K of TSN significantly increased along with raised the concentration of extract from Toosendan Fructus

indicated passive absorption.Absorption of TSN in duodenum

jejunum

ileum was quick with no significant differences

but absorption of TSN in colon was slow. Conclusion: Absorption of TSN at different sections of intestine conformed to zero order model with a pattern of passive absorption.

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Related Author

BAO Xing-jie1

SU Shu-lan1

DUAN Jin-ao2

HUA Yong-qing2

TANG Yu-ping2

SHANG Er-xin2

CHEN Yan1

Related Institution

Guangxi University of Chinese Medicine

Chengdu University of Traditional Chinese Medicine

Xiamen Institute of Medicine,Xiamen Institute for Drug Control

Wuhan University College of Pharmacy

Zhaoqing Medical College

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