Influence of Active Compounds of Angelicae Dahuricae Radix on the Intestinal Absorption of Active Components of Compatibility of Drug Pairs Using Everted Gut Sac Model
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Influence of Active Compounds of Angelicae Dahuricae Radix on the Intestinal Absorption of Active Components of Compatibility of Drug Pairs Using Everted Gut Sac Model
Chinese Journal of Experimental Traditional Medical FormulaeVol. 19, Issue 17, Pages: 193-197(2013)
LIANG Xin-li, ZHAO Guo-wei, Luo Yun, et al. Influence of Active Compounds of Angelicae Dahuricae Radix on the Intestinal Absorption of Active Components of Compatibility of Drug Pairs Using Everted Gut Sac Model[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(17): 193-197.
DOI:
LIANG Xin-li, ZHAO Guo-wei, Luo Yun, et al. Influence of Active Compounds of Angelicae Dahuricae Radix on the Intestinal Absorption of Active Components of Compatibility of Drug Pairs Using Everted Gut Sac Model[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(17): 193-197. DOI: 10.11653/syfj2013170193.
Influence of Active Compounds of Angelicae Dahuricae Radix on the Intestinal Absorption of Active Components of Compatibility of Drug Pairs Using Everted Gut Sac Model
Objective: To investigate the influence of active compounds of Angelicae Dahuricae Radix(coumarin/volatile oil) on the intestinal absorption of puerarin
baicalin
ferelic
liquiritin and glycyrrhizic acid
respectively. To explore the influence law of Angelicae Dahricae Radix on the intestinal absorption of the active compounds of herb-pairs. Method: Everted gut sac was used to study compatible effects of Angelicae Dahuricae Radix and herb-pairs(Puerariae Lobatae Radix
Scutellariae Radix
Chuanxiong Rhizoma
Glycyrrhizae Radix et Rhizoma) on intestinal absorption of puerarin
baicalin
ferelic acid
liquiritin and glycyrrhizic acid. Result: Results showed that Angelicae Dahuricae Radix could enhance the absorption of puerarin(1.7 times ) and baicalin (4.74 times )
and has no effect on the intestinal absorption of ferulic acid
but could significantly restrain the intestinal absorption of liquiritin and glycyrrhizic acid. Conclusion: These results confirmed that synergistic therapeutic effect of compatibility of Angelicae Dahuricae Radix and Puerariae Lobatae Radix
Angelicae Dahuricae Radix and Scutellariae Radix not only lay in the different active ingredients acting on the different target
but also shown as active compounds of Radix Angelicae dahuricae could increasing the intestinal absorption of puerarin and baicalin. The mechanism of Angelicae Dahuricae Radix and Chuangxiong Rhizoma
Angelicae Dahuricae Radix and Glycyrrhizae Radix et Rhizoma may be not related to the influence of Angelicae Dahuricae Radix on the intestinal absorption of ferulic acid
Correlation Analysis Between Microbial Community Changes and Medicinal Quality Formation During Processing of Angelicae Dahuricae Radix
Differences in Intestinal Absorption Characteristics of Nanophase in Single and Combined Decoctions of Ginseng Radix et Rhizoma and Zingiberis Rhizoma Recens Based on Everted Gut Sac Model
Investigation of Intestinal Absorption Characteristics of Multi-index Components of Danggui Buxuetang Based on Drug Absorption Simulating System
Construction of A Microfluidic Intestine-liver-breast Cancer Chip and Analysis of Its Application in PK-PD in Vitro of Drugs
Effect of Berbamine Hydrochloride on Intestinal Absorption Characteristics of Berberine Hydrochloride by Rat Everted Intestinal Sac Model
Related Author
CHEN Xiaoyan
ZHU Xinglong
GAN Qingxia
WANG Jiahao
AN Guangqin
WU Qinghua
PEI Jin
MA Yuntong
Related Institution
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The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital