Objective: To study the anti-diabetic activity of amentoflavone (AMT) in diabetic mice

and to lay the foundation for the further research and development. Method: Male Kunming mice were injected intraperitoneally (ip) with streptozotocin(STZ

180 mg·kg-1) to induce diabetic model. Then

the diabetic mice were treated with AMT (30

60

120

240

480 mg·kg-1) for 2 weeks. During the administration

food and water intake was recorded. After administration for 2 weeks

the serum levels of fasting blood glucose(FBG)

oral glucose tolerance test(OGTT) and insulin were measured

meanwhile pathologic-morphological of pancreas was observed by HE staining

to authenticate the antidiabetic activity of AMT and to find out the optimum dose. Result: All the dose of AMT(30

60

120

240

480 mg·kg-1) could decrease the food and water intake and FBG

and ameliorate the OGTT.Meanwhile

amentoflavone could improve islet tissue repair function. Conclusion: AMT can ameliorate the glucose disorder

regulate insulin secretion and restore the pancreas.