Syndrome Identification of Abnormal Glucose Metabolism in Metabolic Syndrome Rat Based on Syndrome Detecting from Recipe Used

JIANG Nan; ZHANG Bing-bing; PU Ji; ZHANG Wen-shun; MA Xian-de; SHI Yan

doi:10.11653/syfj2013170211

您当前的位置：

首页 >

文章列表页 >

Syndrome Identification of Abnormal Glucose Metabolism in Metabolic Syndrome Rat Based on Syndrome Detecting from Recipe Used

更新时间：2024-01-04

- Syndrome Identification of Abnormal Glucose Metabolism in Metabolic Syndrome Rat Based on Syndrome Detecting from Recipe Used
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 17, Pages: 211-216(2013)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.11653/syfj2013170211
  CLC：
- Published：2013
- 稿件说明：
移动端阅览
JIANG Nan, ZHANG Bing-bing, PU Ji, et al. Syndrome Identification of Abnormal Glucose Metabolism in Metabolic Syndrome Rat Based on Syndrome Detecting from Recipe Used[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(17): 211-216.
DOI：

JIANG Nan, ZHANG Bing-bing, PU Ji, et al. Syndrome Identification of Abnormal Glucose Metabolism in Metabolic Syndrome Rat Based on Syndrome Detecting from Recipe Used[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(17): 211-216. DOI： 10.11653/syfj2013170211.

摘要

目的: 用"以方测证法" 探讨糖代谢异常的代谢综合征(MS)大鼠可能出现的中医证型。方法: 在建立糖代谢异常的MS大鼠模型后

用随机对照表法按血糖高低随机分为MS组、A组、B组、C组、D组。用4个方剂:大柴胡汤(A组

9.4 g·kg-1)、黄连温胆汤(B组

10.4 g·kg-1)、知柏地黄丸(C组

15.1 g·kg-1)、血府逐瘀汤(D组

7.8 g·kg-1)

于造模12周后ig给药

持续3周。于12周和15周末

检测其体重、血压、空腹血糖、甘油三酯、高密度脂蛋白胆固醇(HDL-C)及胰岛素(FINS)水平。结果: 第15周时

与模型组比较A~D组体重、血压、空腹血糖(FBG)均无显著差异

D组TG水平显著降低(P<0.05或P<0.01)

B组HDL-C显著升高(P<0.05)

A~D组FINS和胰岛素抵抗指数(HOMA-IR)显著降低(P<0.01)。结论: 糖代谢异常的MS大鼠可能同时存在肝胃郁热证、痰热互结证、阴虚热盛证、血瘀脉络证4种证型。不是单独存在

而是病理因素相互夹杂

混合在一起所组成的复合证型

出现于糖代谢异常的MS大鼠中。

Abstract

Objective: To explore TCM syndromes in abnormalglucose metabolism metabolic syndrome(MS) rats based on syndrome detecting from recipe used. Method: After the establishment of the MS rat model

according to blood sugar level

rats were randomly divided into MS group

group A

group B

group C

group D. Chaihu Tang

Huanglian Wendan Tang

Zhibai Dihuang Wan and Xuefu Zhuyu Tang were given. At week 12 and 15 the weight

blood pressure

fasting blood glucose(FBG)

triglycerides(TG)

high density lipoprotein(HDL-C) and insulin levels were measured. Result: Compared with the model group

in A

D group

body weight

blood pressureand FBG had no significant difference

in A

B and D groups TG level significantly decreased

and in B group HDL-C was significantly increased (P<0.05)

in A and D group fasting insulin(FINS) and homeostasis model assessment insulin resistance(HOMA-IR) were significantly lowered (P<0.01). Conclusion: Abnormal glucose metabolism MS rats may exist hepatogastric stagnant heat

phlegm each node certificate

Yin Heat Syndrome and blood stasis syndrome

and the four syndromes indicated mixed signs.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Syndrome Identification of Abnormal Glucose Metabolism in Metabolic Syndrome Rat Based on Syndrome Detecting from Recipe Used

Clinical Observation of Modified Huanglian Wendantang in Treatment of Cardiovascular Risk Factors in Patients with Metabolic Syndrome Under Guidance of Treating Disease before Its Onset

Effect and Mechanism of Prunellae Spica on Metabolic Syndrome in Rats

Effect of Qingfei Xiegantang on Chronic Inflammation and Endothelial Function with Metabolic Syndrome

Mechanism of Pinelliae Rhizoma-Citri Exocarpium Rubrum in Treatment of Metabolic Syndrome Based on Network Pharmacology

Related Author

HAN Yi

HAN Yubo

ZOU Guoliang

WANG Ruinan

YAO Chunli

DONG Xinyu

LIU Li

LI Li

Related Institution

Heilongjiang University of Chinese Medicine

First Affiliated Hospital of Heilongjiang University of Chinese Medicine

Hunan University of Chinese Medicine

Hunan Brain Hospital （The Second People's Hospital of Hunan Province）

Medical College of Yanbian University，Yanbian

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰