TONG Yan, LI Na, Li Rui, et al. Effects of Salt-processing Eucommiae Cortex on BMD and Serum IGF-I in Rats after Ovariectomy[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(17): 255-257.
DOI:
TONG Yan, LI Na, Li Rui, et al. Effects of Salt-processing Eucommiae Cortex on BMD and Serum IGF-I in Rats after Ovariectomy[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(17): 255-257. DOI: 10.11653/syfj2013170255.
Effects of Salt-processing Eucommiae Cortex on BMD and Serum IGF-I in Rats after Ovariectomy
Objective: To observe the effects of salt-processing Eucommiae Cortex on BMD and serum hormone in rats after ovariectomy. Method: The model of postmenopausal osteoporosis was developed by ovariectomy
the rats were randomly divided into six groups
including sham operation group
model group
Nilestriol group
and salt-processing Eucommiae Cortex high
moderate
low-dose group(6
3
1.5 g·kg-1
ig)7 days later
successive administration was carried out
lasted for 12 weeks. The lumbar spine and femoral bone BMC and BMD
serum E2 and IGF-I content were assayed. Result: Compared with control group
BMC and BMD in model group rats decreased obviously
serum E2
IGF-I level decreased.Compared with model group
salt-processing Eucommiae Cortex could increase BMC and BMD
and serum E2
IGF-I level in rats after ovariectomy(P<0.05). Conclusion: Processing can enhance the anti-osteoporosis effect of Duzhong
salt-processing Eucommiae Cortex can prevent and delay osteoporosis in rats after ovariectomy by increasing serum E2
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