Anti-diabetic Effects of Danzhi Jiangtang Capsule on Experimental Diabetic Rats

XU Xian-xiang; WANG Ning-qing; XIA Lun-zhu; FANG Zhao-hui

doi:10.11653/syfj2013170288

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Anti-diabetic Effects of Danzhi Jiangtang Capsule on Experimental Diabetic Rats

更新时间：2024-01-04

- Anti-diabetic Effects of Danzhi Jiangtang Capsule on Experimental Diabetic Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 17, Pages: 288-290(2013)
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- DOI：10.11653/syfj2013170288
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- Published：2013
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XU Xian-xiang, WANG Ning-qing, XIA Lun-zhu, et al. Anti-diabetic Effects of Danzhi Jiangtang Capsule on Experimental Diabetic Rats[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(17): 288-290.
DOI：

XU Xian-xiang, WANG Ning-qing, XIA Lun-zhu, et al. Anti-diabetic Effects of Danzhi Jiangtang Capsule on Experimental Diabetic Rats[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(17): 288-290. DOI： 10.11653/syfj2013170288.

摘要

目的: 观察丹蛭降糖胶囊对实验性糖尿病大鼠的降糖作用。方法: 大鼠静脉注射链脲佐菌素致实验性糖尿病模型

随机分为模型组、盐酸苯乙双胍组(75 mg·kg-1)、糖脉康组(1.5 g·kg-1)和丹蛭降糖胶囊高、中、低剂量组(生药13

6.5

3.2 g·kg-1)

每组8只

另选8只正常大鼠为正常对照组

给药20 d后

观察各组大鼠体重、血糖、糖耐量、糖化血红蛋白及胰岛素水平的变化。结果: 丹蛭降糖胶囊高剂量组能显著降低糖尿病大鼠空腹血糖(P<0.01)

改善糖耐量(P<0.01);各剂量组均能显著增加糖尿病大鼠的体重(P<0.01

P<0.01

P<0.05)、降低糖化血红蛋白水平(P<0.01

P<0.01

P<0.01);而不影响胰岛素水平。结论: 丹蛭降糖胶囊对实验性糖尿病大鼠有显著降糖作用。

Abstract

Objective: To investigate the anti-diabetic effect of Danzhi Jiangtang capsule (DJC) on experimental diabetic rats. Method: Experimental diabetic model in rats was induced by the injection of streptozocin. The models were divided randomly into 6 groups:model group (normal saline ig)

phenformin hydrochloride group (75 mg·kg-1

ig)

Tangmaikang group (1.5 g·kg-1

ig) and DJC low

middle

high dose (13

6.5

3.2 g·kg-1

ig) groups (n=8 each). Rats were selected as normal group (nomal saline ig). After 20 days of administration

effects of body weight

blood glucose

glucose tolerance and insulin level of rats were observed. Result: The DJC high dose group could significantly decrease level of fasting blood glucose (P<0.01) and improve glucose tolerance (P<0.01). All the DJC groups could significantly increase body weight of diabetic rats (P<0.01

P<0.05) and decrease level of glycosylated serum protein (P<0.01). No obvious effect of DJC on insulin level. Conclusion: DJC has significant anti-diabetic effect on experimental diabetic rats.

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