Objective: To discuss the clinical efficacy of Tianma Gouteng decoction in Preeclampsia patients. Method: Eighty patients were randomly divided into observation group (n=40) and control group (n=40). Patients in the two groups were both treated with conventional western therapy. Tianma Gouteng Decoction was used in the observation group (1 dose per day

2-3 as a cycle). Blood pressure

pregnancy time

birth weight

1 min Apgar score

maternal complications

perinatal mortality

24 h urinary protein excretion

serum nitric oxide (NO) and endothelin-1 (ET-1)level were monitored. Result: Systolic blood pressure and diastdic blood pressure of the observation group was lower than the control group (P<0.05

P<0.01). Termination of pregnancy time of the observation group were late than the control group

birth weight heavier than the control group

cases of the maternal complications were fewer than the control group

member of 1 min Apgar score greater than 7 was more than the control group (P<0.05

P<0.01);After treatment

24 h urinary protein of the observation group were lower than the control group (P<0.01);NO level were significantly increased in both groups

ET-1 level of the observation group was significantly lower than the observation group(P<0.01). Conclusion: Tianma Gouteng decoction can control blood pressure of the patient with severe preeclampsia

improve symptoms

prolong gestational age and improve outcomes of Perinatal Fetus

it also can regulate vascular endothelial function and is worth to further research worthy of clinical use.