Objective: To discuss the clinical efficacy of heat-clearing and detoxifying resuscitation method on patients with severe hand-foot-and-mouth disease(HFMD) and the protection effect on brain

heart

lungs. Method: ninety patients with HFMD were randomly divided into observation group(n=45) and control group(n=45). Control group was given conventional therapy according to 'Hand-foot-mouth disease treatment guidelines (2010 Edition)’. Reduning injection and traditional Chinese medicine were added to observation group by using heat-clearing and detoxifying resuscitation method. Body temperature returned to normal time

Rash

bleb subsidise time

the healing time of oral ulcer and hospital stay of patients were observed. The SPO2 and PaO2 of the 0 day and 3th day were tested;the Aspartate aminotransferase(AST)

Lactate dehydrogenase(LDH)

Creatine kinase(CK)

Isoenzymes of creatine kinase(CK-MB) and Neuron specific enolase(NSE) of 0 day and 5th day were tested. Result: The body temperature returned to normal time

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bleb subsidise time

the healing time of oral ulcer and hospital stay of patients in observation group were lower than control group (P<0.05).The SPO2 and PaO2 level of the 3th day in observation group were higher than control group (P<0.01);the CK and CK-MB level of the 5th day in observation group were lower than control group (P<0.05

P<0.01);the NSE level of the 5th day in observation group were lower than control group (P<0.01). Conclusion: Heat-clearing and detoxifying resuscitation method can Shorten the course of HFMD disease

and it can protect brain

heart

lungs of patients. It is worthy of clinical application.