Effect of Xiaoshuan Capsule on Hemorheology and Vascular Endothelial Function in Patients with Cerebral Ischemic Stroke of Qi Deficiency and Blood Stasis Type

YANG Hai-yan; ZHU Pan|long; WANG Xin|zhi

doi:10.11653/syfj2013170342

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Effect of Xiaoshuan Capsule on Hemorheology and Vascular Endothelial Function in Patients with Cerebral Ischemic Stroke of Qi Deficiency and Blood Stasis Type

更新时间：2024-01-04

- Effect of Xiaoshuan Capsule on Hemorheology and Vascular Endothelial Function in Patients with Cerebral Ischemic Stroke of Qi Deficiency and Blood Stasis Type
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 17, Pages: 342-346(2013)
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- DOI：10.11653/syfj2013170342
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- Published：2013
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YANG Hai-yan, ZHU Pan|long, WANG Xin|zhi. Effect of Xiaoshuan Capsule on Hemorheology and Vascular Endothelial Function in Patients with Cerebral Ischemic Stroke of Qi Deficiency and Blood Stasis Type[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(17): 342-346.
DOI：

YANG Hai-yan, ZHU Pan|long, WANG Xin|zhi. Effect of Xiaoshuan Capsule on Hemorheology and Vascular Endothelial Function in Patients with Cerebral Ischemic Stroke of Qi Deficiency and Blood Stasis Type[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(17): 342-346. DOI： 10.11653/syfj2013170342.

摘要

目的: 观察消栓胶囊对缺血性中风(CIS)气虚血瘀型患者疗效和血流变学、血管内皮功能指标的影响

探讨消栓胶囊对CIS的作用机制。方法: 80例CIS气虚血瘀证患者按数字表法随机分为消栓组和对照组各40例。对照组用常规治疗方法治疗

消栓组在常规治疗的基础上加服消栓(肠溶)胶囊 0.4 g/次

3次·d-1

两组患者均连续治疗3个月。于治疗前后评估神经功能缺损评分、日常生活能力评分

检测血流变学和血管内皮功能指标的变化情况。结果: 治疗前两组患者的NIHSS评分、Barthel指数、血流变学、血脂及血管内皮功能指标比较差异无统计学意义

具有可比性;治疗前两组患者血流变学、血脂及血管内皮功能指标与健康组比较差异有统计学意义(均P<0.01);治疗后

消栓组的总有效率高于对照组(P<0.05);消栓组患者NIHSS评分、Barthel指数、血流变学及血管内皮功能指标的改善均优于对照组(P<0.05或P<0.01);消栓组未发现明显的不良反应。结论: 消栓胶囊治疗气虚血瘀型CIS患者安全有效

其机制可能是通过改善血流变学、血管内皮功能来实现的。

Abstract

Objective: To observe the effect of Xiaoshuan capsule on hemorheology and vascular endothelial function in patients with cerebral ischemic stroke of qi deficiency and blood stasis type

to evaluate the possible mechanisms in patients with CIS. Method: Eighty patients with CIS of qi deficiency and blood stasis type were randomLy divided into two groups:the control group (40 cases) was given conventional treatment methods;Xiaoshuan group (40 cases) was given Xiaoshuan capsule 0.4 g once

three times daily. These patients of two groups were treated for 3 months. The scores of neurological deficit and activities of daily living were evaluated

and changes in blood rheology and endothelial function indicators were observed before and after treatment. Result: Before the treatment

indicator of national Institutes of health stroke scale(NIHSS) score

Barthel index

blood rheology

blood lipids and vascular endothelial function indicators were no significant difference between two groups. Before treatment

there were significant difference in these indicators between two groups and the health group(all P<0.01);after treatment

total efficiency in Xiaoshuan group was higher than that in control group(P<0.05);NIHSS score

Barthel Index

blood rheology and vascular endothelial function indicators in the Xiaoshuan patients were better than that in the control group(P<0.05 or P<0.01);Xiaoshuan capsule had no adverse reactions. Conclusion: It is safe and effective that Xiaoshuan capsule in the treatment of patients with cerebral ischemic stroke of qi deficiency and blood stasis type

the mechanism may be achieved through improving blood rheology

vascular endothelial function.

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Related Institution

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