RAO Tao, LI Dong-xun, HE Xiu-ju, et al. Preparation and Identification of -Hederagenin-Hydroxypropyl--Cyclodextrin Inclusion Complex[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(18): 1-4.
DOI:
RAO Tao, LI Dong-xun, HE Xiu-ju, et al. Preparation and Identification of -Hederagenin-Hydroxypropyl--Cyclodextrin Inclusion Complex[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(18): 1-4. DOI: 10.11653/syfj2013180001.
Preparation and Identification of -Hederagenin-Hydroxypropyl--Cyclodextrin Inclusion Complex
Objective: To prepare and identify α-hederagenin-hydroxypropyl-β-cyclodextrin inclusion complex (BD-HP-β-CD). Method: BD-HP-β-CD was prepared by saturated aqueous solution.With yield of inclusion complex and entrapment efficiency as indexes
effects of temperature
time and stirring speed on inclusion technology was investigated by orthogonal design.Phase of BD-HP-β-CD was characterized by X-ray diffractometry(XRD) and differential scanning calorimetry(DSC)
solubilization effect of HP-β-CD to BD was investigated by phase solubility method. Result: Optimum inclusion technology was as following:inclusion temperature of 37 ℃
stirring speed 300 r·min-1
inclusion time 2 h.Average yield of inclusion complex was 93.3%
encapsulation efficiency was 70.7%
apparent solubility of BD-HP-β-CD compared to BD in pH 8.5
1.2
6.8 medium increased by about 4
60
200 times
disappearance of BD characteristic peak in XRD and DSC confirmed that inclusion has been formed. Conclusion: HP-β-CD could significantly improve solubility and dissolution of BD.
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