Optimization of Preparation Technology of Compound Liquorice Double-Deck Tablets by Orthogonal Test

ZHU Xiao-xiao; MOU Zhi-gang; YAO Xiao-juan; TAO Shan-shan; ZHONG Jian-yu; XIAO Fang-yuan; HU Yan

doi:10.11653/syfj2013180045

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Optimization of Preparation Technology of Compound Liquorice Double-Deck Tablets by Orthogonal Test

更新时间：2024-01-04

- Optimization of Preparation Technology of Compound Liquorice Double-Deck Tablets by Orthogonal Test
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 18, Pages: 45-47(2013)
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- DOI：10.11653/syfj2013180045
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- Published：2013
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ZHU Xiao-xiao, MOU Zhi-gang, YAO Xiao-juan, et al. Optimization of Preparation Technology of Compound Liquorice Double-Deck Tablets by Orthogonal Test[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(18): 45-47.
DOI：

ZHU Xiao-xiao, MOU Zhi-gang, YAO Xiao-juan, et al. Optimization of Preparation Technology of Compound Liquorice Double-Deck Tablets by Orthogonal Test[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(18): 45-47. DOI： 10.11653/syfj2013180045.

摘要

目的: 优选复方甘草片的片芯制备工艺。方法: 以片芯崩解时限、溶出度和外观为综合评价指标

通过正交试验考察微晶纤维素、羧甲基淀粉钠(CMS-Na)、滑石粉、氧化镁(MgO)用量对复方甘草片双层片片芯制备工艺的影响。结果: 最佳制备工艺为5.6%微晶纤维素为填充剂

15.2% CMS-Na为崩解剂

4.9%滑石粉为润滑剂

5.1%氧化镁为吸收剂

制备的片芯外表光洁

崩解时限(26.4±10) s

溶出度达99%。结论: 优选的制备工艺稳定可行

制得的片芯达到了双层片制备的要求。

Abstract

Objective: To optimize preparation technology of tablets core of compound liquorice double-deck tablets. Method: With disintegration time of tablets core

dissolution and appearance as comprehensive evaluation index

orthogonal test was adopted to optimize preparation technology of compound liquorice tablets with the amount of microcrystalline cellulose

sodium carboxymethyl starch(CMS-Na)

french chalk and magnesium oxide(MgO) as factors. Result: Optimum preparation technology was as following:5.6% microcrystalline cellulose as stuffing bulking agent

15.2% CMS-Na as disintegrating agent

4.9% french chalk as lubricant and 5.1% MgO as absorbent. Surface of prepared tablets were smooth with disintegration time of (26.4±10) s and dissolution of 99%. Conclusion: Prepared tablets core conformed to requirements of double-deck tablets

optimized technology was stable and feasible.

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