Objective: To investigate productive technology and quality of Yansukang aerosols after changed excipient. Method: Through observing uniformity of mixture of liquid and propellant

Yansukang aerosol prescription was screened

with total press times as index to optimize tetrafluoroethane filling volume

leakage rate

residual

appearance were taken as qualitative and quantitative indicators to make comparative study on Yansukang aerosols before and after propellant changed. Result: Mixture of liquid and propellant was homogeneous without stratification phenomenon;When tetrafluoroethane filling volume was 4.5 g

total press times was almost the same with that before propellant changed;Leakage rate

residual

droplet size distribution of in vitro spray and simulated distribution of in vivo micro-particles distribution

appearance and so on all had no significant difference. Conclusion: Product prescription was not necessary to be adjusted after change of propellant and quantitative valve.Filling volume of tetrafluoroethane should be adjusted from 2.5 g to 4.5 g.Productive technology was controllable and stable

quality of Yansukang aerosols was consistent before and after propellant changed.