Objective: To control quality stability of Chinese materia medica pieces by stepwise blending method. Method: Scutellariae Radix was chosen as research object

with the contents of baicalin

baicalein and wogonin as indexes

five batches of Scutellariae Radix were blended to get one target cruse drug using stepwise blending method

fingerprint similarity was used to verity quality consistency of Scutellariae Radix. Result: RSD of the contents of index components between blending pieces and objective piece was less than 5%

fingerprint similarity between blending pieces and objective piece was 0.986. Conclusion: After different batches of pieces were handled by stepwise blending method

RSD of index components content reduced and fingerprint similarity tended to be consistent

then quality uniformity of Chinese materia medica increased significantly.Stepwise blending method was accurate and simple without complexity mathematical software

which could be a new method for blending of Chinese materia medica pieces.