WU He-zhen, FU Cong, YANG Yan-fang, et al. Transdermal Test of Ephedrine and Pseudoephedrine from Tianxing Kechuan Patches in Rats[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(18): 58-61.
DOI:
WU He-zhen, FU Cong, YANG Yan-fang, et al. Transdermal Test of Ephedrine and Pseudoephedrine from Tianxing Kechuan Patches in Rats[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(18): 58-61. DOI: 10.11653/syfj2013180058.
Transdermal Test of Ephedrine and Pseudoephedrine from Tianxing Kechuan Patches in Rats
Objective: To determinate in vitro transdermal rates of ephedrine hydrochloride and pseudoephedrine hydrochloride from Tianxing Kechuan patches in rats. Method: Accepted physiological saline as receiving medium
the contents of percutaneous ephedrine hydrochloride and pseudoephedrine hydrochloride were determined by HPLC
in vitro transdermal rate of two index ingredients from Tianxing Kechuan patches was investigated. Result: Cumulative transdermal rates of ephedrine and pseudoephedrine in 24 hours were 12.37% and 12.04%
respectively
and in 36 hours were 14.81% and 14.34%
respectively. Conclusion: In vitro transdermal rates of ephedrine and pseudoephedrine from Tianxing Kechuan patches in rats were high
which provided basis for clinical efficacy studies of this preparation.
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