Objective: To observe the effect of prescription with function of relieving the exterior syndrome on upper respiratory tract infection in mice model through regulating mucosal immunity. Method: The mouse model of upper respiratory tract mucosal immunity dysfunction was induced by cold stimulation. Then the effects of prescription were evaluated by secretory immunoglobulin A(S-IgA) and lysozyme activity in saliva of the mice. Furthermore

the modeling mice received separately intranasal infection and intraperitoneal injection of streptococcus pneumoniae. The effects of prescription were evaluated by mortality and survival time. The antibacterial activities by in vitro experiment were observed. Result: Mahuang decoction and Yinqiao Powder could significantly improve the lysozyme activity in the saliva of the mice. In addition

Mahuang decoction also could enhance the S-IgA in the saliva of the animal. In the mice infected by streptococcus pneumoniae via nasal

Mahuang decoction could reduce the mortality rate and prolong survive time. But Mahuang decoction and Yinqiao powder had no protective effect on the upper respiratory tract mucosal immune dysfunction induced by streptococcus pneumoniae intraperitoneal injection. Moreover

no antibacterial ability on streptococcus pneumoniae in vitro was found. Conclusion: The prescription with function of relieving the exterior syndrome may prevent the upper respiratory infection through improving the function of upper respiratory mucosal immune system.