Objective: To observe the anticonvulsant effect of Bupleuri Radix(BR) and Paeoniae Radix Alba(PA) with different compatibility proportion in mice. Method: The Kunming mice were randomly divided into seven groups:the model group(A)

the positive control group(B)

BR-PA2:1 group(C)

BR-PA1:1group(D)

BR group(E)

PA group(F)

RB-PA1:2 group(G).The positive control group received the administration ofphenytoin 0.025 g·kg-1 or diazepam 0.004 g·kg-1

the dosage of BR and PA with different compatibility proportion was 10.4 g·kg-1

and the model group received the same amount of saline.After the continuous lavage administration for 7 days

we tested the anticonvulsant effect of BR and PA with different compatibility proportion in mouse models of maximal electroskock(MES)

pentylenetetrazole(PTZ)

strychnine and pilocarpine-induced convulsions 60 min after the last administration

the latency of clonic convulsion

tonic convulsion and death were observed. Result: In MES model

compared with group A

group B and F could significantly decrease the incidence of seizures (P<0.05); in PTZ model

group B

C

D could significantly prolong the latency of clonic

convulsions and tonic convulsions(P<0.05)

group B

C could obviously prolong the latency of death;in strychnine model

all groups except group B(P<0.05) had no effect on the latency of clonic and death; in pilocarpine model

compared with group A

all groups could prolong the latency of death (P<0.05). Conclusion: Bupluri Radix and Paeoniae Radix Alba with application compatibility display commendable anticonvulsant effect

which is better than Bupluri Radix or Paeoniae Radix Alba alone

anticonvulsant effect of BR and PA group with ratio of 2: 1 is best.